Early Delivery of Misfolded PrP from ER to Lysosomes by Autophagy

Prion diseases are linked to the accumulation of a misfolded isoform (PrP(Sc)) of prion protein (PrP). Evidence suggests that lysosomes are degradation endpoints and sites of the accumulation of PrP(Sc). We questioned whether lysosomes participate in the early quality control of newly generated misf...

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Detalles Bibliográficos
Autores principales: Cortes, Constanza J., Qin, Kefeng, Norstrom, Eric M., Green, William N., Bindokas, Vytautas P., Mastrianni, James A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2013
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3877647/
https://www.ncbi.nlm.nih.gov/pubmed/24454378
http://dx.doi.org/10.1155/2013/560421

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3877647/
https://www.ncbi.nlm.nih.gov/pubmed/24454378
http://dx.doi.org/10.1155/2013/560421

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