Structural basis for Ca(2+) selectivity of a voltage-gated calcium channel

Voltage-gated calcium (Ca(V)) channels catalyze rapid, highly selective influx of Ca(2+) into cells despite 70-fold higher extracellular concentration of Na(+). How Ca(V) channels solve this fundamental biophysical problem remains unclear. Here we report physiological and crystallographic analyses o...

Descripción completa

Detalles Bibliográficos
Autores principales: Tang, Lin, Gamal El-Din, Tamer M., Payandeh, Jian, Martinez, Gilbert Q., Heard, Teresa M., Scheuer, Todd, Zheng, Ning, Catterall, William A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2013
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3877713/
https://www.ncbi.nlm.nih.gov/pubmed/24270805
http://dx.doi.org/10.1038/nature12775

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3877713/
https://www.ncbi.nlm.nih.gov/pubmed/24270805
http://dx.doi.org/10.1038/nature12775

Ejemplares similares