Cargando…

Structural basis for Ca(2+) selectivity of a voltage-gated calcium channel

Voltage-gated calcium (Ca(V)) channels catalyze rapid, highly selective influx of Ca(2+) into cells despite 70-fold higher extracellular concentration of Na(+). How Ca(V) channels solve this fundamental biophysical problem remains unclear. Here we report physiological and crystallographic analyses o...

Descripción completa

Detalles Bibliográficos
Autores principales:	Tang, Lin, Gamal El-Din, Tamer M., Payandeh, Jian, Martinez, Gilbert Q., Heard, Teresa M., Scheuer, Todd, Zheng, Ning, Catterall, William A.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	2013
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3877713/ https://www.ncbi.nlm.nih.gov/pubmed/24270805 http://dx.doi.org/10.1038/nature12775

Ejemplares similares

THE CRYSTAL STRUCTURE OF A VOLTAGE-GATED SODIUM CHANNEL
por: Payandeh, Jian, et al.
Publicado: (2011)

A gating charge interaction required for late slow inactivation of the bacterial sodium channel NavAb
por: Gamal El-Din, Tamer M., et al.
Publicado: (2013)

Tracking S4 movement by gating pore currents in the bacterial sodium channel NaChBac
por: Gamal El-Din, Tamer M., et al.
Publicado: (2014)

Structural basis for severe pain caused by mutations in the S4-S5 linkers of voltage-gated sodium channel Na(V)1.7
por: Wisedchaisri, Goragot, et al.
Publicado: (2023)

Molecular Determinants of Brevetoxin Binding to Voltage-Gated Sodium Channels
por: Konoki, Keiichi, et al.
Publicado: (2019)

Fenestropathy of Voltage-Gated Sodium Channels
por: Gamal El-Din, Tamer M., et al.
Publicado: (2022)

Cell-cycle arrest at the G1/S boundary enhances transient voltage-gated ion channel expression in human and insect cells
por: Eltokhi, Ahmed, et al.
Publicado: (2023)

Editorial: Structure Related Druggability of Voltage-Gated Sodium and Calcium Ion-Channels to Treat Diseases
por: Gamal El-Din, Tamer M., et al.
Publicado: (2022)

Structural basis for voltage-sensor trapping of the cardiac sodium channel by a deathstalker scorpion toxin
por: Jiang, Daohua, et al.
Publicado: (2021)

Ion permeation and block of the gating pore in the voltage sensor of Na(V)1.4 channels with hypokalemic periodic paralysis mutations
por: Sokolov, Stanislav, et al.
Publicado: (2010)

Structural Basis for Gating Pore Current in Periodic Paralysis
por: Jiang, Daohua, et al.
Publicado: (2018)

Druggability of Voltage-Gated Sodium Channels—Exploring Old and New Drug Receptor Sites
por: Wisedchaisri, Goragot, et al.
Publicado: (2022)

Neutralization of Gating Charges in Domain II of the Sodium Channel α Subunit Enhances Voltage-Sensor Trapping by a β-Scorpion Toxin
por: Cestèle, Sandrine, et al.
Publicado: (2001)

Overview of the voltage-gated sodium channel family
por: Yu, Frank H, et al.
Publicado: (2003)

Structural Basis of the Modulation of the Voltage‐Gated Calcium Ion Channel Ca(v)1.1 by Dihydropyridine Compounds
por: Gao, Shuai, et al.
Publicado: (2020)

Molecular and biophysical basis of glutamate and trace metal modulation of voltage-gated Ca(v)2.3 calcium channels
por: Shcheglovitov, Aleksandr, et al.
Publicado: (2012)

Molecular and biophysical basis of glutamate and trace metal modulation of voltage-gated Ca(v)2.3 calcium channels
por: Shcheglovitov, Aleksandr, et al.
Publicado: (2012)

Convergent regulation of Ca(V)1.2 channels by direct phosphorylation and by the small GTPase RAD in the cardiac fight-or-flight response
por: Hovey, Liam, et al.
Publicado: (2022)

Molecular insights into the gating mechanisms of voltage-gated calcium channel Ca(V)2.3
por: Gao, Yiwei, et al.
Publicado: (2023)

The hitchhiker’s guide to the voltage-gated sodium channel galaxy
por: Ahern, Christopher A., et al.
Publicado: (2016)

Increased intracellular magnesium attenuates β-adrenergic stimulation of the cardiac Ca(V)1.2 channel
por: Brunet, Sylvain, et al.
Publicado: (2013)

Molecular Analysis of the Putative Inactivation Particle in the Inactivation Gate of Brain Type IIA Na(+) Channels
por: Kellenberger, Stephan, et al.
Publicado: (1997)

Molecular Analysis of Potential Hinge Residues in the Inactivation Gate of Brain Type IIA Na(+) Channels
por: Kellenberger, Stephan, et al.
Publicado: (1997)

BARP suppresses voltage-gated calcium channel activity and Ca(2+)-evoked exocytosis
por: Béguin, Pascal, et al.
Publicado: (2014)

Conotoxins as Tools to Understand the Physiological Function of Voltage-Gated Calcium (Ca(V)) Channels
por: Ramírez, David, et al.
Publicado: (2017)

Optogenetic Control of Voltage‐Gated Calcium Channels
por: Ma, Guolin, et al.
Publicado: (2018)

Functions of Presynaptic Voltage-gated Calcium Channels
por: Dolphin, Annette C
Publicado: (2020)

RGK regulation of voltage-gated calcium channels
por: Zafir, BURAEI, et al.
Publicado: (2015)

The life cycle of voltage-gated Ca(2+) channels in neurons: an update on the trafficking of neuronal calcium channels
por: Ferron, Laurent, et al.
Publicado: (2021)

Structural basis for pore blockade of human voltage-gated calcium channel Ca(v)1.3 by motion sickness drug cinnarizine
por: Yao, Xia, et al.
Publicado: (2022)

Localization of the Activation Gate of a Voltage-gated Ca(2+) Channel
por: Xie, Cheng, et al.
Publicado: (2005)

Structural basis for the regulation of L-type voltage-gated calcium channels: interactions between the N-terminal cytoplasmic domain and Ca(2+)-calmodulin
por: Liu, Zhihong, et al.
Publicado: (2012)

Upregulation of Voltage-Gated Calcium Channel Ca(v)1.3 in Bovine Somatotropes Treated with Ghrelin
por: Salinas Zarate, V. M., et al.
Publicado: (2013)

Calmodulin regulation (calmodulation) of voltage-gated calcium channels
por: Ben-Johny, Manu, et al.
Publicado: (2014)

Roles and Regulation of Voltage-gated Calcium Channels in Arrhythmias
por: Kushner, Jared, et al.
Publicado: (2019)

Structural determinants of voltage-gating properties in calcium channels
por: Fernández-Quintero, Monica L, et al.
Publicado: (2021)

Cooperative regulation of Ca(v)1.2 channels by intracellular Mg(2+), the proximal C-terminal EF-hand, and the distal C-terminal domain
por: Brunet, Sylvain, et al.
Publicado: (2009)

Modulation of Ca(V)1.2 Channels by Mg(2+) Acting at an EF-hand Motif in the COOH-terminal Domain
por: Brunet, Sylvain, et al.
Publicado: (2005)

Molecular basis of the interaction between gating modifier spider toxins and the voltage sensor of voltage-gated ion channels
por: Lau, Carus H. Y., et al.
Publicado: (2016)

Role of individual S4 segments in gating of Ca(v)3.1 T-type calcium channel by voltage
por: Jurkovicova-Tarabova, Bohumila, et al.
Publicado: (2018)

Cannot write session to /tmp/vufind_sessions/sess_ar8i0mqcbpmg09t2o4sruv09n1