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Lessons learnt recruiting to a multi-site UK cohort study to explore recovery of health and well-being after colorectal cancer (CREW study)

BACKGROUND: The UK leads the world in recruitment of patients to cancer clinical trials, with a six-fold increase in recruitment during 2001–2010. However, there are large variations across cancer centres. This paper details recruitment to a large multi-centre prospective cohort study and discusses...

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Autores principales: Fenlon, Deborah, Chivers Seymour, Kim, Okamoto, Ikumi, Winter, Jane, Richardson, Alison, Addington-Hall, Julia, Corner, Jessica L, Smith, Peter W, May, Christine M, Breckons, Matthew, Foster, Claire
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2013
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3877869/
https://www.ncbi.nlm.nih.gov/pubmed/24373214
http://dx.doi.org/10.1186/1471-2288-13-153
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author Fenlon, Deborah
Chivers Seymour, Kim
Okamoto, Ikumi
Winter, Jane
Richardson, Alison
Addington-Hall, Julia
Corner, Jessica L
Smith, Peter W
May, Christine M
Breckons, Matthew
Foster, Claire
author_facet Fenlon, Deborah
Chivers Seymour, Kim
Okamoto, Ikumi
Winter, Jane
Richardson, Alison
Addington-Hall, Julia
Corner, Jessica L
Smith, Peter W
May, Christine M
Breckons, Matthew
Foster, Claire
author_sort Fenlon, Deborah
collection PubMed
description BACKGROUND: The UK leads the world in recruitment of patients to cancer clinical trials, with a six-fold increase in recruitment during 2001–2010. However, there are large variations across cancer centres. This paper details recruitment to a large multi-centre prospective cohort study and discusses lessons learnt to enhance recruitment. METHODS: During CREW (ColoREctal Wellbeing) cohort study set up and recruitment, data were systematically collected on all centres that applied to participate, time from study approval to first participant recruited and the percentage of eligible patients recruited into the study. RESULTS: 30 participating NHS cancer centres were selected through an open competition via the cancer networks. Time from study approval to first participant recruited took a median 124 days (min 53, max 290). Of 1350 eligible people in the study time frame, 78% (n = 1056) were recruited into the study, varying from 30-100% eligible across centres. Recruitment of 1056 participants took 17 months. CONCLUSION: In partnership with the National Cancer Research Network, this successful study prioritised relationship building and education. Key points for effective recruitment: pre-screening and selection of centres; nurses as PIs; attendance at study days; frequent communication and a reduced level of consent to enhance uptake amongst underrepresented groups.
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spelling pubmed-38778692014-01-03 Lessons learnt recruiting to a multi-site UK cohort study to explore recovery of health and well-being after colorectal cancer (CREW study) Fenlon, Deborah Chivers Seymour, Kim Okamoto, Ikumi Winter, Jane Richardson, Alison Addington-Hall, Julia Corner, Jessica L Smith, Peter W May, Christine M Breckons, Matthew Foster, Claire BMC Med Res Methodol Research Article BACKGROUND: The UK leads the world in recruitment of patients to cancer clinical trials, with a six-fold increase in recruitment during 2001–2010. However, there are large variations across cancer centres. This paper details recruitment to a large multi-centre prospective cohort study and discusses lessons learnt to enhance recruitment. METHODS: During CREW (ColoREctal Wellbeing) cohort study set up and recruitment, data were systematically collected on all centres that applied to participate, time from study approval to first participant recruited and the percentage of eligible patients recruited into the study. RESULTS: 30 participating NHS cancer centres were selected through an open competition via the cancer networks. Time from study approval to first participant recruited took a median 124 days (min 53, max 290). Of 1350 eligible people in the study time frame, 78% (n = 1056) were recruited into the study, varying from 30-100% eligible across centres. Recruitment of 1056 participants took 17 months. CONCLUSION: In partnership with the National Cancer Research Network, this successful study prioritised relationship building and education. Key points for effective recruitment: pre-screening and selection of centres; nurses as PIs; attendance at study days; frequent communication and a reduced level of consent to enhance uptake amongst underrepresented groups. BioMed Central 2013-12-28 /pmc/articles/PMC3877869/ /pubmed/24373214 http://dx.doi.org/10.1186/1471-2288-13-153 Text en Copyright © 2013 Fenlon et al.; licensee BioMed Central Ltd. http://creativecommons.org/licenses/by/2.0 This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Article
Fenlon, Deborah
Chivers Seymour, Kim
Okamoto, Ikumi
Winter, Jane
Richardson, Alison
Addington-Hall, Julia
Corner, Jessica L
Smith, Peter W
May, Christine M
Breckons, Matthew
Foster, Claire
Lessons learnt recruiting to a multi-site UK cohort study to explore recovery of health and well-being after colorectal cancer (CREW study)
title Lessons learnt recruiting to a multi-site UK cohort study to explore recovery of health and well-being after colorectal cancer (CREW study)
title_full Lessons learnt recruiting to a multi-site UK cohort study to explore recovery of health and well-being after colorectal cancer (CREW study)
title_fullStr Lessons learnt recruiting to a multi-site UK cohort study to explore recovery of health and well-being after colorectal cancer (CREW study)
title_full_unstemmed Lessons learnt recruiting to a multi-site UK cohort study to explore recovery of health and well-being after colorectal cancer (CREW study)
title_short Lessons learnt recruiting to a multi-site UK cohort study to explore recovery of health and well-being after colorectal cancer (CREW study)
title_sort lessons learnt recruiting to a multi-site uk cohort study to explore recovery of health and well-being after colorectal cancer (crew study)
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3877869/
https://www.ncbi.nlm.nih.gov/pubmed/24373214
http://dx.doi.org/10.1186/1471-2288-13-153
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