New Sinularianin Sesquiterpenes from Soft Coral Sinularia sp.

Four new sesquiterpenes, sinularianins C–F (3–6), together with known sinularianins A (1) and B (2) were identified from a South China Sea soft coral Sinularia sp. Compounds 1–6 were evaluated for inhibition of NF-κB activation using the cell-based HEK293 NF-κB luciferase reporter gene assay. Compou...

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Detalles Bibliográficos
Autores principales: Yang, Bin, Liao, Shengrong, Lin, Xiuping, Wang, Junfeng, Liu, Juan, Zhou, Xuefeng, Yang, Xianwen, Liu, Yonghong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2013
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3877883/
https://www.ncbi.nlm.nih.gov/pubmed/24317466
http://dx.doi.org/10.3390/md11124741
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author Yang, Bin
Liao, Shengrong
Lin, Xiuping
Wang, Junfeng
Liu, Juan
Zhou, Xuefeng
Yang, Xianwen
Liu, Yonghong
author_facet Yang, Bin
Liao, Shengrong
Lin, Xiuping
Wang, Junfeng
Liu, Juan
Zhou, Xuefeng
Yang, Xianwen
Liu, Yonghong
author_sort Yang, Bin
collection PubMed
description Four new sesquiterpenes, sinularianins C–F (3–6), together with known sinularianins A (1) and B (2) were identified from a South China Sea soft coral Sinularia sp. Compounds 1–6 were evaluated for inhibition of NF-κB activation using the cell-based HEK293 NF-κB luciferase reporter gene assay. Compounds 1 and 4 were exhibited a potent effect with inhibitory rates of 41.3% and 43.0% at the concentration of 10 µg/mL, respectively.
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spelling pubmed-38778832014-01-02 New Sinularianin Sesquiterpenes from Soft Coral Sinularia sp. Yang, Bin Liao, Shengrong Lin, Xiuping Wang, Junfeng Liu, Juan Zhou, Xuefeng Yang, Xianwen Liu, Yonghong Mar Drugs Article Four new sesquiterpenes, sinularianins C–F (3–6), together with known sinularianins A (1) and B (2) were identified from a South China Sea soft coral Sinularia sp. Compounds 1–6 were evaluated for inhibition of NF-κB activation using the cell-based HEK293 NF-κB luciferase reporter gene assay. Compounds 1 and 4 were exhibited a potent effect with inhibitory rates of 41.3% and 43.0% at the concentration of 10 µg/mL, respectively. MDPI 2013-12-02 /pmc/articles/PMC3877883/ /pubmed/24317466 http://dx.doi.org/10.3390/md11124741 Text en © 2013 by the authors; licensee MDPI, Basel, Switzerland. http://creativecommons.org/licenses/by/3.0/ This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/3.0/).
spellingShingle Article
Yang, Bin
Liao, Shengrong
Lin, Xiuping
Wang, Junfeng
Liu, Juan
Zhou, Xuefeng
Yang, Xianwen
Liu, Yonghong
New Sinularianin Sesquiterpenes from Soft Coral Sinularia sp.
title New Sinularianin Sesquiterpenes from Soft Coral Sinularia sp.
title_full New Sinularianin Sesquiterpenes from Soft Coral Sinularia sp.
title_fullStr New Sinularianin Sesquiterpenes from Soft Coral Sinularia sp.
title_full_unstemmed New Sinularianin Sesquiterpenes from Soft Coral Sinularia sp.
title_short New Sinularianin Sesquiterpenes from Soft Coral Sinularia sp.
title_sort new sinularianin sesquiterpenes from soft coral sinularia sp.
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3877883/
https://www.ncbi.nlm.nih.gov/pubmed/24317466
http://dx.doi.org/10.3390/md11124741
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