Accumulation of Fascin(+) cells during experimental autoimmune neuritis

BACKGROUND: Experimental autoimmune neuritis (EAN) is a well-known animal model of human demyelinating polyneuropathies and is characterized by inflammation and demyelination in the peripheral nervous system. Fascin is an evolutionarily highly conserved cytoskeletal protein of 55 kDa containing two...

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Autores principales: Yang, Zichen, Sun, Jian, Yang, Xiaofeng, Zhang, Zhiyuan, Lou, Bangwei, Xiong, Jian, Schluesener, Hermann J, Zhang, Zhiren
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2013
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3877979/
https://www.ncbi.nlm.nih.gov/pubmed/24369046
http://dx.doi.org/10.1186/1746-1596-8-213
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author Yang, Zichen
Sun, Jian
Yang, Xiaofeng
Zhang, Zhiyuan
Lou, Bangwei
Xiong, Jian
Schluesener, Hermann J
Zhang, Zhiren
author_facet Yang, Zichen
Sun, Jian
Yang, Xiaofeng
Zhang, Zhiyuan
Lou, Bangwei
Xiong, Jian
Schluesener, Hermann J
Zhang, Zhiren
author_sort Yang, Zichen
collection PubMed
description BACKGROUND: Experimental autoimmune neuritis (EAN) is a well-known animal model of human demyelinating polyneuropathies and is characterized by inflammation and demyelination in the peripheral nervous system. Fascin is an evolutionarily highly conserved cytoskeletal protein of 55 kDa containing two actin binding domains that cross-link filamentous actin to hexagonal bundles. METHODS: Here we have studied by immunohistochemistry the spatiotemporal accumulation of Fascin + cells in sciatic nerves of EAN rats. RESULTS: A robust accumulation of Fascin + cell was observed in the peripheral nervous system of EAN which was correlated with the severity of neurological signs in EAN. CONCLUSION: Our results suggest a pathological role of Fascin in EAN. VIRTUAL SLIDES: The virtual slides for this article can be found here: http://www.diagnosticphatology.diagnomx.eu/vs/6734593451114811
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spelling pubmed-38779792014-01-03 Accumulation of Fascin(+) cells during experimental autoimmune neuritis Yang, Zichen Sun, Jian Yang, Xiaofeng Zhang, Zhiyuan Lou, Bangwei Xiong, Jian Schluesener, Hermann J Zhang, Zhiren Diagn Pathol Research BACKGROUND: Experimental autoimmune neuritis (EAN) is a well-known animal model of human demyelinating polyneuropathies and is characterized by inflammation and demyelination in the peripheral nervous system. Fascin is an evolutionarily highly conserved cytoskeletal protein of 55 kDa containing two actin binding domains that cross-link filamentous actin to hexagonal bundles. METHODS: Here we have studied by immunohistochemistry the spatiotemporal accumulation of Fascin + cells in sciatic nerves of EAN rats. RESULTS: A robust accumulation of Fascin + cell was observed in the peripheral nervous system of EAN which was correlated with the severity of neurological signs in EAN. CONCLUSION: Our results suggest a pathological role of Fascin in EAN. VIRTUAL SLIDES: The virtual slides for this article can be found here: http://www.diagnosticphatology.diagnomx.eu/vs/6734593451114811 BioMed Central 2013-12-25 /pmc/articles/PMC3877979/ /pubmed/24369046 http://dx.doi.org/10.1186/1746-1596-8-213 Text en Copyright © 2013 Yang et al.; licensee BioMed Central Ltd. http://creativecommons.org/licenses/by/2.0 This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.
spellingShingle Research
Yang, Zichen
Sun, Jian
Yang, Xiaofeng
Zhang, Zhiyuan
Lou, Bangwei
Xiong, Jian
Schluesener, Hermann J
Zhang, Zhiren
Accumulation of Fascin(+) cells during experimental autoimmune neuritis
title Accumulation of Fascin(+) cells during experimental autoimmune neuritis
title_full Accumulation of Fascin(+) cells during experimental autoimmune neuritis
title_fullStr Accumulation of Fascin(+) cells during experimental autoimmune neuritis
title_full_unstemmed Accumulation of Fascin(+) cells during experimental autoimmune neuritis
title_short Accumulation of Fascin(+) cells during experimental autoimmune neuritis
title_sort accumulation of fascin(+) cells during experimental autoimmune neuritis
topic Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3877979/
https://www.ncbi.nlm.nih.gov/pubmed/24369046
http://dx.doi.org/10.1186/1746-1596-8-213
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