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Brain localization of Kaposi’s sarcoma in a patient treated by combination antiretroviral therapy
BACKGROUND: Central nervous system is a very rare site of Kaposi’s sarcoma in acquired immunodeficiency syndrome. Kaposi’s sarcoma, a neoplasm of endothelial origin, occurs mainly in the skin, but can involve many tissues, especially in patients with a poor immunity. Combination antiretroviral thera...
Autores principales: | , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BioMed Central
2013
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3878088/ https://www.ncbi.nlm.nih.gov/pubmed/24359263 http://dx.doi.org/10.1186/1471-2334-13-600 |
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author | Baldini, Francesco Baiocchini, Andrea Schininà, Vincenzo Agrati, Chiara Giancola, Maria Letizia Alba, Lucia Grisetti, Susanna Del Nonno, Franca Capobianchi, Maria Rosaria Antinori, Andrea |
author_facet | Baldini, Francesco Baiocchini, Andrea Schininà, Vincenzo Agrati, Chiara Giancola, Maria Letizia Alba, Lucia Grisetti, Susanna Del Nonno, Franca Capobianchi, Maria Rosaria Antinori, Andrea |
author_sort | Baldini, Francesco |
collection | PubMed |
description | BACKGROUND: Central nervous system is a very rare site of Kaposi’s sarcoma in acquired immunodeficiency syndrome. Kaposi’s sarcoma, a neoplasm of endothelial origin, occurs mainly in the skin, but can involve many tissues, especially in patients with a poor immunity. Combination antiretroviral therapy, highly active against human immunodeficiency virus type-1, has caused a dramatic reduction of cutaneous and visceral involvements. No report of central nervous system localization of Kaposi’s sarcoma is described since the introduction of combination antiretroviral therapy in the late 90’s. CASE PRESENTATION: A 42 year-old Caucasian man affected by human immunodeficiency virus type-1 infection treated with combination antiretroviral therapy and showing relatively preserved immunity with low viral load presented gingival squamous cell carcinoma and visceral (lungs and lymph nodes) Kaposi’s sarcoma. Chemotherapy and radiotherapy were performed with improvement of both neoplasms. Afterwards, a magnetic resonance imaging showed focal lesions of the brain. Despite new chemotherapy and radiotherapy the patient died. Histology after autopsy revealed brain lesions due to Kaposi’s sarcoma with the detection of Human Herpesvirus 8 on tissue samples. CONCLUSIONS: This is the first report in the combination antiretroviral therapy era of a very rare complication of Kaposi’s sarcoma, such as that of brain localization, in a patient with a relatively good control of human immunodeficiency virus infection. Therefore, Kaposi’s sarcoma should be considered in differential diagnosis with other intracranial mass lesions that can occur in human immunodeficiency virus infected-patients focusing the issue of appropriate treatment for central nervous system involvement. |
format | Online Article Text |
id | pubmed-3878088 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2013 |
publisher | BioMed Central |
record_format | MEDLINE/PubMed |
spelling | pubmed-38780882014-01-03 Brain localization of Kaposi’s sarcoma in a patient treated by combination antiretroviral therapy Baldini, Francesco Baiocchini, Andrea Schininà, Vincenzo Agrati, Chiara Giancola, Maria Letizia Alba, Lucia Grisetti, Susanna Del Nonno, Franca Capobianchi, Maria Rosaria Antinori, Andrea BMC Infect Dis Case Report BACKGROUND: Central nervous system is a very rare site of Kaposi’s sarcoma in acquired immunodeficiency syndrome. Kaposi’s sarcoma, a neoplasm of endothelial origin, occurs mainly in the skin, but can involve many tissues, especially in patients with a poor immunity. Combination antiretroviral therapy, highly active against human immunodeficiency virus type-1, has caused a dramatic reduction of cutaneous and visceral involvements. No report of central nervous system localization of Kaposi’s sarcoma is described since the introduction of combination antiretroviral therapy in the late 90’s. CASE PRESENTATION: A 42 year-old Caucasian man affected by human immunodeficiency virus type-1 infection treated with combination antiretroviral therapy and showing relatively preserved immunity with low viral load presented gingival squamous cell carcinoma and visceral (lungs and lymph nodes) Kaposi’s sarcoma. Chemotherapy and radiotherapy were performed with improvement of both neoplasms. Afterwards, a magnetic resonance imaging showed focal lesions of the brain. Despite new chemotherapy and radiotherapy the patient died. Histology after autopsy revealed brain lesions due to Kaposi’s sarcoma with the detection of Human Herpesvirus 8 on tissue samples. CONCLUSIONS: This is the first report in the combination antiretroviral therapy era of a very rare complication of Kaposi’s sarcoma, such as that of brain localization, in a patient with a relatively good control of human immunodeficiency virus infection. Therefore, Kaposi’s sarcoma should be considered in differential diagnosis with other intracranial mass lesions that can occur in human immunodeficiency virus infected-patients focusing the issue of appropriate treatment for central nervous system involvement. BioMed Central 2013-12-21 /pmc/articles/PMC3878088/ /pubmed/24359263 http://dx.doi.org/10.1186/1471-2334-13-600 Text en Copyright © 2013 Baldini et al.; licensee BioMed Central Ltd. http://creativecommons.org/licenses/by/2.0 This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated. |
spellingShingle | Case Report Baldini, Francesco Baiocchini, Andrea Schininà, Vincenzo Agrati, Chiara Giancola, Maria Letizia Alba, Lucia Grisetti, Susanna Del Nonno, Franca Capobianchi, Maria Rosaria Antinori, Andrea Brain localization of Kaposi’s sarcoma in a patient treated by combination antiretroviral therapy |
title | Brain localization of Kaposi’s sarcoma in a patient treated by combination antiretroviral therapy |
title_full | Brain localization of Kaposi’s sarcoma in a patient treated by combination antiretroviral therapy |
title_fullStr | Brain localization of Kaposi’s sarcoma in a patient treated by combination antiretroviral therapy |
title_full_unstemmed | Brain localization of Kaposi’s sarcoma in a patient treated by combination antiretroviral therapy |
title_short | Brain localization of Kaposi’s sarcoma in a patient treated by combination antiretroviral therapy |
title_sort | brain localization of kaposi’s sarcoma in a patient treated by combination antiretroviral therapy |
topic | Case Report |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3878088/ https://www.ncbi.nlm.nih.gov/pubmed/24359263 http://dx.doi.org/10.1186/1471-2334-13-600 |
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