Resolution of left atrial appendage thrombus with apixaban

Left atrial appendage (LAA) thrombosis is an important cause of cardiogenic cerebral thromboembolism. Apixaban is a member of the class of novel oral anticoagulants (NOAC) and is superior to warfarin in preventing stroke or systemic embolism, causes less bleeding, and results in lower mortality in p...

Descripción completa

Detalles Bibliográficos
Autores principales: Kawakami, Tohru, Kobayakawa, Hiroko, Ohno, Hiroyoshi, Tanaka, Nobukiyo, Ishihara, Hiroki
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2013
Materias:
Case Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3878218/
https://www.ncbi.nlm.nih.gov/pubmed/24359320
http://dx.doi.org/10.1186/1477-9560-11-26
_version_ 1782297761953087488
author Kawakami, Tohru
Kobayakawa, Hiroko
Ohno, Hiroyoshi
Tanaka, Nobukiyo
Ishihara, Hiroki
author_facet Kawakami, Tohru
Kobayakawa, Hiroko
Ohno, Hiroyoshi
Tanaka, Nobukiyo
Ishihara, Hiroki
author_sort Kawakami, Tohru
collection PubMed
description Left atrial appendage (LAA) thrombosis is an important cause of cardiogenic cerebral thromboembolism. Apixaban is a member of the class of novel oral anticoagulants (NOAC) and is superior to warfarin in preventing stroke or systemic embolism, causes less bleeding, and results in lower mortality in patients with atrial fibrillation. There are few reports of resolution of LAA thrombus with other NOAC. We present a 72-year-old male patient with persistent atrial fibrillation associated with left atrial thrombus. Sixteen days of apixaban treatment showed complete thrombus resolution. In this study, soluble fibrin and D-dimer levels decreased without prolongation of international normalized ratio (INR) and activated partial thromboplastin time (APTT).
format Online
Article
Text
id pubmed-3878218
institution National Center for Biotechnology Information
language English
publishDate 2013
publisher BioMed Central
record_format MEDLINE/PubMed
spelling pubmed-38782182014-01-03 Resolution of left atrial appendage thrombus with apixaban Kawakami, Tohru Kobayakawa, Hiroko Ohno, Hiroyoshi Tanaka, Nobukiyo Ishihara, Hiroki Thromb J Case Report Left atrial appendage (LAA) thrombosis is an important cause of cardiogenic cerebral thromboembolism. Apixaban is a member of the class of novel oral anticoagulants (NOAC) and is superior to warfarin in preventing stroke or systemic embolism, causes less bleeding, and results in lower mortality in patients with atrial fibrillation. There are few reports of resolution of LAA thrombus with other NOAC. We present a 72-year-old male patient with persistent atrial fibrillation associated with left atrial thrombus. Sixteen days of apixaban treatment showed complete thrombus resolution. In this study, soluble fibrin and D-dimer levels decreased without prolongation of international normalized ratio (INR) and activated partial thromboplastin time (APTT). BioMed Central 2013-12-20 /pmc/articles/PMC3878218/ /pubmed/24359320 http://dx.doi.org/10.1186/1477-9560-11-26 Text en Copyright © 2013 Kawakami et al.; licensee BioMed Central Ltd. http://creativecommons.org/licenses/by/2.0 This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.
spellingShingle Case Report
Kawakami, Tohru
Kobayakawa, Hiroko
Ohno, Hiroyoshi
Tanaka, Nobukiyo
Ishihara, Hiroki
Resolution of left atrial appendage thrombus with apixaban
title Resolution of left atrial appendage thrombus with apixaban
title_full Resolution of left atrial appendage thrombus with apixaban
title_fullStr Resolution of left atrial appendage thrombus with apixaban
title_full_unstemmed Resolution of left atrial appendage thrombus with apixaban
title_short Resolution of left atrial appendage thrombus with apixaban
title_sort resolution of left atrial appendage thrombus with apixaban
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3878218/
https://www.ncbi.nlm.nih.gov/pubmed/24359320
http://dx.doi.org/10.1186/1477-9560-11-26
work_keys_str_mv AT kawakamitohru resolutionofleftatrialappendagethrombuswithapixaban
AT kobayakawahiroko resolutionofleftatrialappendagethrombuswithapixaban
AT ohnohiroyoshi resolutionofleftatrialappendagethrombuswithapixaban
AT tanakanobukiyo resolutionofleftatrialappendagethrombuswithapixaban
AT ishiharahiroki resolutionofleftatrialappendagethrombuswithapixaban

Ejemplares similares