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Cardiovascular Autonomic Neuropathy in Context of Other Complications of Type 2 Diabetes Mellitus

The aim of this study was to investigate the relationship between cardiac autonomic neuropathy (CAN) and other micro- and macrovascular complications and risk factors for type 2 diabetes. We included, in this study, 149 patients with type 2 diabetes. We evaluated their cardiovascular risk factors, d...

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Autores principales: Moţăţăianu, Anca, Bălaşa, Rodica, Voidăzan, Septimiu, Bajkó, Zoltán
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2013
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3878280/
https://www.ncbi.nlm.nih.gov/pubmed/24455698
http://dx.doi.org/10.1155/2013/507216
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author Moţăţăianu, Anca
Bălaşa, Rodica
Voidăzan, Septimiu
Bajkó, Zoltán
author_facet Moţăţăianu, Anca
Bălaşa, Rodica
Voidăzan, Septimiu
Bajkó, Zoltán
author_sort Moţăţăianu, Anca
collection PubMed
description The aim of this study was to investigate the relationship between cardiac autonomic neuropathy (CAN) and other micro- and macrovascular complications and risk factors for type 2 diabetes. We included, in this study, 149 patients with type 2 diabetes. We evaluated their cardiovascular risk factors, demographic data, and any major micro- and macrovascular complications of their diabetes. Assessments of CAN were based upon Ewing's battery. Results. CAN was present in 38.9% of patients. In the CAN group, the duration of diabetes, BMI, systolic blood pressure, lipid levels, and HBA1c were all significantly higher than those in the other group. A significant association was found between CAN and retinopathy, peripheral neuropathy, ABI, and IMT. Multivariate logistic regression demonstrated that, in type 2 diabetes, the odds of CAN (OR (95% confidence intervals)) increase with the age of the patients (1.68 (1,4129–2.0025)), the average diabetes duration (0.57 (0.47–0.67)), cholesterol (1.009 (1.00-1.01)), HbA1c levels (1.88 (1.31–2.72)), peripheral neuropathy (15.47 (5.16–46.38)), BMI (1.12 (1.05–1.21)), and smoking (2.21 (1.08–4.53)). Conclusions. This study shows that CAN in type 2 diabetes is significantly associated with other macro- and microvascular complications and that there are important modifiable risk factors for its development.
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spelling pubmed-38782802014-01-19 Cardiovascular Autonomic Neuropathy in Context of Other Complications of Type 2 Diabetes Mellitus Moţăţăianu, Anca Bălaşa, Rodica Voidăzan, Septimiu Bajkó, Zoltán Biomed Res Int Clinical Study The aim of this study was to investigate the relationship between cardiac autonomic neuropathy (CAN) and other micro- and macrovascular complications and risk factors for type 2 diabetes. We included, in this study, 149 patients with type 2 diabetes. We evaluated their cardiovascular risk factors, demographic data, and any major micro- and macrovascular complications of their diabetes. Assessments of CAN were based upon Ewing's battery. Results. CAN was present in 38.9% of patients. In the CAN group, the duration of diabetes, BMI, systolic blood pressure, lipid levels, and HBA1c were all significantly higher than those in the other group. A significant association was found between CAN and retinopathy, peripheral neuropathy, ABI, and IMT. Multivariate logistic regression demonstrated that, in type 2 diabetes, the odds of CAN (OR (95% confidence intervals)) increase with the age of the patients (1.68 (1,4129–2.0025)), the average diabetes duration (0.57 (0.47–0.67)), cholesterol (1.009 (1.00-1.01)), HbA1c levels (1.88 (1.31–2.72)), peripheral neuropathy (15.47 (5.16–46.38)), BMI (1.12 (1.05–1.21)), and smoking (2.21 (1.08–4.53)). Conclusions. This study shows that CAN in type 2 diabetes is significantly associated with other macro- and microvascular complications and that there are important modifiable risk factors for its development. Hindawi Publishing Corporation 2013 2013-12-18 /pmc/articles/PMC3878280/ /pubmed/24455698 http://dx.doi.org/10.1155/2013/507216 Text en Copyright © 2013 Anca Moţăţăianu et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Clinical Study
Moţăţăianu, Anca
Bălaşa, Rodica
Voidăzan, Septimiu
Bajkó, Zoltán
Cardiovascular Autonomic Neuropathy in Context of Other Complications of Type 2 Diabetes Mellitus
title Cardiovascular Autonomic Neuropathy in Context of Other Complications of Type 2 Diabetes Mellitus
title_full Cardiovascular Autonomic Neuropathy in Context of Other Complications of Type 2 Diabetes Mellitus
title_fullStr Cardiovascular Autonomic Neuropathy in Context of Other Complications of Type 2 Diabetes Mellitus
title_full_unstemmed Cardiovascular Autonomic Neuropathy in Context of Other Complications of Type 2 Diabetes Mellitus
title_short Cardiovascular Autonomic Neuropathy in Context of Other Complications of Type 2 Diabetes Mellitus
title_sort cardiovascular autonomic neuropathy in context of other complications of type 2 diabetes mellitus
topic Clinical Study
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3878280/
https://www.ncbi.nlm.nih.gov/pubmed/24455698
http://dx.doi.org/10.1155/2013/507216
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