Successful Management of Hydroxyurea-induced Leg Ulcers in Essential Thrombocythemia: Report of 3 Cases

Essential thrombocythemia is one of the myeloproliferative neoplasms with a plethora of thrombohemorrhagic complications. Hydroxyurea has been proven to be an effective treatment for this condition. However, it is not without side effects. We herein report 3 patients with essential thrombocythemia t...

Descripción completa

Detalles Bibliográficos
Autores principales: Rahal, Jihane Abou, Ishak, Rim S., Otrock, Zaher K., Maakaron, Joseph E., Ghosn, Samer, Taher, Ali T.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Galenos Publishing 2013
Materias:
Case Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3878479/
https://www.ncbi.nlm.nih.gov/pubmed/24385783
http://dx.doi.org/10.4274/Tjh.2012.0134
_version_ 1782297812753448960
author Rahal, Jihane Abou
Ishak, Rim S.
Otrock, Zaher K.
Maakaron, Joseph E.
Ghosn, Samer
Taher, Ali T.
author_facet Rahal, Jihane Abou
Ishak, Rim S.
Otrock, Zaher K.
Maakaron, Joseph E.
Ghosn, Samer
Taher, Ali T.
author_sort Rahal, Jihane Abou
collection PubMed
description Essential thrombocythemia is one of the myeloproliferative neoplasms with a plethora of thrombohemorrhagic complications. Hydroxyurea has been proven to be an effective treatment for this condition. However, it is not without side effects. We herein report 3 patients with essential thrombocythemia treated with hydroxyurea who developed refractory leg ulcers, and we outline their successful management. We also review the literature to shed light on the mechanism of this toxicity. Awareness of this important treatment complication is important to avoid the pitfall of futile invasive interventions.
format Online
Article
Text
id pubmed-3878479
institution National Center for Biotechnology Information
language English
publishDate 2013
publisher Galenos Publishing
record_format MEDLINE/PubMed
spelling pubmed-38784792014-01-02 Successful Management of Hydroxyurea-induced Leg Ulcers in Essential Thrombocythemia: Report of 3 Cases Rahal, Jihane Abou Ishak, Rim S. Otrock, Zaher K. Maakaron, Joseph E. Ghosn, Samer Taher, Ali T. Turk J Haematol Case Report Essential thrombocythemia is one of the myeloproliferative neoplasms with a plethora of thrombohemorrhagic complications. Hydroxyurea has been proven to be an effective treatment for this condition. However, it is not without side effects. We herein report 3 patients with essential thrombocythemia treated with hydroxyurea who developed refractory leg ulcers, and we outline their successful management. We also review the literature to shed light on the mechanism of this toxicity. Awareness of this important treatment complication is important to avoid the pitfall of futile invasive interventions. Galenos Publishing 2013-06 2013-06-05 /pmc/articles/PMC3878479/ /pubmed/24385783 http://dx.doi.org/10.4274/Tjh.2012.0134 Text en © Turkish Journal of Hematology, Published by Galenos Publishing. http://creativecommons.org/licenses/by/2.5/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Case Report
Rahal, Jihane Abou
Ishak, Rim S.
Otrock, Zaher K.
Maakaron, Joseph E.
Ghosn, Samer
Taher, Ali T.
Successful Management of Hydroxyurea-induced Leg Ulcers in Essential Thrombocythemia: Report of 3 Cases
title Successful Management of Hydroxyurea-induced Leg Ulcers in Essential Thrombocythemia: Report of 3 Cases
title_full Successful Management of Hydroxyurea-induced Leg Ulcers in Essential Thrombocythemia: Report of 3 Cases
title_fullStr Successful Management of Hydroxyurea-induced Leg Ulcers in Essential Thrombocythemia: Report of 3 Cases
title_full_unstemmed Successful Management of Hydroxyurea-induced Leg Ulcers in Essential Thrombocythemia: Report of 3 Cases
title_short Successful Management of Hydroxyurea-induced Leg Ulcers in Essential Thrombocythemia: Report of 3 Cases
title_sort successful management of hydroxyurea-induced leg ulcers in essential thrombocythemia: report of 3 cases
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3878479/
https://www.ncbi.nlm.nih.gov/pubmed/24385783
http://dx.doi.org/10.4274/Tjh.2012.0134
work_keys_str_mv AT rahaljihaneabou successfulmanagementofhydroxyureainducedlegulcersinessentialthrombocythemiareportof3cases
AT ishakrims successfulmanagementofhydroxyureainducedlegulcersinessentialthrombocythemiareportof3cases
AT otrockzaherk successfulmanagementofhydroxyureainducedlegulcersinessentialthrombocythemiareportof3cases
AT maakaronjosephe successfulmanagementofhydroxyureainducedlegulcersinessentialthrombocythemiareportof3cases
AT ghosnsamer successfulmanagementofhydroxyureainducedlegulcersinessentialthrombocythemiareportof3cases
AT taheralit successfulmanagementofhydroxyureainducedlegulcersinessentialthrombocythemiareportof3cases

Ejemplares similares