Identification of Age-Related Macular Degeneration Related Genes by Applying Shortest Path Algorithm in Protein-Protein Interaction Network

This study attempted to find novel age-related macular degeneration (AMD) related genes based on 36 known AMD genes. The well-known shortest path algorithm, Dijkstra's algorithm, was applied to find the shortest path connecting each pair of known AMD related genes in protein-protein interaction...

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Detalles Bibliográficos
Autores principales: Zhang, Jian, Jiang, Min, Yuan, Fei, Feng, Kai-Yan, Cai, Yu-Dong, Xu, Xun, Chen, Lei
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2013
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3878555/
https://www.ncbi.nlm.nih.gov/pubmed/24455700
http://dx.doi.org/10.1155/2013/523415
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author Zhang, Jian
Jiang, Min
Yuan, Fei
Feng, Kai-Yan
Cai, Yu-Dong
Xu, Xun
Chen, Lei
author_facet Zhang, Jian
Jiang, Min
Yuan, Fei
Feng, Kai-Yan
Cai, Yu-Dong
Xu, Xun
Chen, Lei
author_sort Zhang, Jian
collection PubMed
description This study attempted to find novel age-related macular degeneration (AMD) related genes based on 36 known AMD genes. The well-known shortest path algorithm, Dijkstra's algorithm, was applied to find the shortest path connecting each pair of known AMD related genes in protein-protein interaction (PPI) network. The genes occurring in any shortest path were considered as candidate AMD related genes. As a result, 125 novel AMD genes were predicted. The further analysis based on betweenness and permutation test indicates that there are 10 genes involved in the formation or development of AMD and may be the actual AMD related genes with high probability. We hope that this contribution would promote the study of age-related macular degeneration and discovery of novel effective treatments.
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spelling pubmed-38785552014-01-19 Identification of Age-Related Macular Degeneration Related Genes by Applying Shortest Path Algorithm in Protein-Protein Interaction Network Zhang, Jian Jiang, Min Yuan, Fei Feng, Kai-Yan Cai, Yu-Dong Xu, Xun Chen, Lei Biomed Res Int Research Article This study attempted to find novel age-related macular degeneration (AMD) related genes based on 36 known AMD genes. The well-known shortest path algorithm, Dijkstra's algorithm, was applied to find the shortest path connecting each pair of known AMD related genes in protein-protein interaction (PPI) network. The genes occurring in any shortest path were considered as candidate AMD related genes. As a result, 125 novel AMD genes were predicted. The further analysis based on betweenness and permutation test indicates that there are 10 genes involved in the formation or development of AMD and may be the actual AMD related genes with high probability. We hope that this contribution would promote the study of age-related macular degeneration and discovery of novel effective treatments. Hindawi Publishing Corporation 2013 2013-12-18 /pmc/articles/PMC3878555/ /pubmed/24455700 http://dx.doi.org/10.1155/2013/523415 Text en Copyright © 2013 Jian Zhang et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Article
Zhang, Jian
Jiang, Min
Yuan, Fei
Feng, Kai-Yan
Cai, Yu-Dong
Xu, Xun
Chen, Lei
Identification of Age-Related Macular Degeneration Related Genes by Applying Shortest Path Algorithm in Protein-Protein Interaction Network
title Identification of Age-Related Macular Degeneration Related Genes by Applying Shortest Path Algorithm in Protein-Protein Interaction Network
title_full Identification of Age-Related Macular Degeneration Related Genes by Applying Shortest Path Algorithm in Protein-Protein Interaction Network
title_fullStr Identification of Age-Related Macular Degeneration Related Genes by Applying Shortest Path Algorithm in Protein-Protein Interaction Network
title_full_unstemmed Identification of Age-Related Macular Degeneration Related Genes by Applying Shortest Path Algorithm in Protein-Protein Interaction Network
title_short Identification of Age-Related Macular Degeneration Related Genes by Applying Shortest Path Algorithm in Protein-Protein Interaction Network
title_sort identification of age-related macular degeneration related genes by applying shortest path algorithm in protein-protein interaction network
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3878555/
https://www.ncbi.nlm.nih.gov/pubmed/24455700
http://dx.doi.org/10.1155/2013/523415
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