Epigenetic regulation of MDR1 gene through post-translational histone modifications in prostate cancer

BACKGROUND: Multidrug resistance 1 (MDR1) gene encodes for an ATP binding cassette transporter - P-glycoprotein (P-gp) - involved in chemoresistance to taxanes. MDR1 promoter methylation is frequent in prostate carcinoma (PCa), suggesting an epigenetic regulation but no functional correlation has be...

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Detalles Bibliográficos
Autores principales: Henrique, Rui, Oliveira, Ana Isabel, Costa, Vera L, Baptista, Tiago, Martins, Ana Teresa, Morais, António, Oliveira, Jorge, Jerónimo, Carmen
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2013
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3878566/
https://www.ncbi.nlm.nih.gov/pubmed/24344919
http://dx.doi.org/10.1186/1471-2164-14-898

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