Gene expression analysis of Salmonella enterica SPI in macrophages indicates differences between serovars that induce systemic disease from those normally causing enteritis()

Global gene expression of the invasive Salmonella serovars S. Enteritidis and S. Typhimurium, and the less-invasive S. Infantis and S. Hadar was studied during infection of a chicken macrophage cell line. Major functional gene groups responsible for intracellular physiological changes were regulated...

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Autores principales: Imre, Ariel, Bukovinszki, Agnes, Lovell, Margaret A., Li, Hongying, Zhou, Xiangmei, Barrow, Paul A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier Scientific Pub. Co 2013
Materias:
Short Communication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3878769/
https://www.ncbi.nlm.nih.gov/pubmed/24080352
http://dx.doi.org/10.1016/j.vetmic.2013.07.034
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author Imre, Ariel
Bukovinszki, Agnes
Lovell, Margaret A.
Li, Hongying
Zhou, Xiangmei
Barrow, Paul A.
author_facet Imre, Ariel
Bukovinszki, Agnes
Lovell, Margaret A.
Li, Hongying
Zhou, Xiangmei
Barrow, Paul A.
author_sort Imre, Ariel
collection PubMed
description Global gene expression of the invasive Salmonella serovars S. Enteritidis and S. Typhimurium, and the less-invasive S. Infantis and S. Hadar was studied during infection of a chicken macrophage cell line. Major functional gene groups responsible for intracellular physiological changes were regulated similarly in all four serovars. However, SPI1 and SPI4 genes of S. Enteritidis and S. Typhimurium were strongly repressed in the macrophages whereas S. Infantis, S. Hadar and other similar serovars maintained up-regulation of these gene sets. This phenomenon may explain some of the biological differences between invasive and non-invasive Salmonella serovars.
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spelling pubmed-38787692014-01-03 Gene expression analysis of Salmonella enterica SPI in macrophages indicates differences between serovars that induce systemic disease from those normally causing enteritis() Imre, Ariel Bukovinszki, Agnes Lovell, Margaret A. Li, Hongying Zhou, Xiangmei Barrow, Paul A. Vet Microbiol Short Communication Global gene expression of the invasive Salmonella serovars S. Enteritidis and S. Typhimurium, and the less-invasive S. Infantis and S. Hadar was studied during infection of a chicken macrophage cell line. Major functional gene groups responsible for intracellular physiological changes were regulated similarly in all four serovars. However, SPI1 and SPI4 genes of S. Enteritidis and S. Typhimurium were strongly repressed in the macrophages whereas S. Infantis, S. Hadar and other similar serovars maintained up-regulation of these gene sets. This phenomenon may explain some of the biological differences between invasive and non-invasive Salmonella serovars. Elsevier Scientific Pub. Co 2013-12-27 /pmc/articles/PMC3878769/ /pubmed/24080352 http://dx.doi.org/10.1016/j.vetmic.2013.07.034 Text en © 2013 The Authors https://creativecommons.org/licenses/by-nc-nd/3.0/ Open Access under CC BY-NC-ND 3.0 (https://creativecommons.org/licenses/by-nc-nd/3.0/) license
spellingShingle Short Communication
Imre, Ariel
Bukovinszki, Agnes
Lovell, Margaret A.
Li, Hongying
Zhou, Xiangmei
Barrow, Paul A.
Gene expression analysis of Salmonella enterica SPI in macrophages indicates differences between serovars that induce systemic disease from those normally causing enteritis()
title Gene expression analysis of Salmonella enterica SPI in macrophages indicates differences between serovars that induce systemic disease from those normally causing enteritis()
title_full Gene expression analysis of Salmonella enterica SPI in macrophages indicates differences between serovars that induce systemic disease from those normally causing enteritis()
title_fullStr Gene expression analysis of Salmonella enterica SPI in macrophages indicates differences between serovars that induce systemic disease from those normally causing enteritis()
title_full_unstemmed Gene expression analysis of Salmonella enterica SPI in macrophages indicates differences between serovars that induce systemic disease from those normally causing enteritis()
title_short Gene expression analysis of Salmonella enterica SPI in macrophages indicates differences between serovars that induce systemic disease from those normally causing enteritis()
title_sort gene expression analysis of salmonella enterica spi in macrophages indicates differences between serovars that induce systemic disease from those normally causing enteritis()
topic Short Communication
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3878769/
https://www.ncbi.nlm.nih.gov/pubmed/24080352
http://dx.doi.org/10.1016/j.vetmic.2013.07.034
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