Mitochondrial permeability transition pore induces mitochondria injury in Huntington disease

BACKGROUND: Mitochondrial impairment has been implicated in the pathogenesis of Huntington’s disease (HD). However, how mutant huntingtin impairs mitochondrial function and thus contributes to HD has not been fully elucidated. In this study, we used striatal cells expressing wild type (STHdh(Q7/Q7))...

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Detalles Bibliográficos
Autores principales: Quintanilla, Rodrigo A, Jin, Youngnam N, von Bernhardi, Rommy, Johnson, Gail VW
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2013
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3878840/
https://www.ncbi.nlm.nih.gov/pubmed/24330821
http://dx.doi.org/10.1186/1750-1326-8-45

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