Targeting MET kinase with the small-molecule inhibitor amuvatinib induces cytotoxicity in primary myeloma cells and cell lines

BACKGROUND: MET is a receptor tyrosine kinase that is activated by the ligand HGF and this pathway promotes cell survival, migration, and motility. In accordance with its oncogenic role, MET is constitutively active, mutated, or over-expressed in many cancers. Corollary to its impact, inhibition of...

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Detalles Bibliográficos
Autores principales: Phillip, Cornel Joseph, Zaman, Shadia, Shentu, Shujun, Balakrishnan, Kumudha, Zhang, Jiexin, Baladandayuthapani, Veera, Taverna, Pietro, Redkar, Sanjeev, Wang, Michael, Stellrecht, Christine Marie, Gandhi, Varsha
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2013
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3878866/
https://www.ncbi.nlm.nih.gov/pubmed/24326130
http://dx.doi.org/10.1186/1756-8722-6-92

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