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Postprandial changes of lipoprotein profile: effect of abdominal obesity

BACKGROUND: Majority of studies that focused on the influence of abdominal obesity on lipoprotein profile, were conducted in the fasting conditions. The effects of visceral fat accumulation on postprandial lipoprotein concentrations have not yet been studied in details. We therefore focused on the p...

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Autores principales: Sabaka, Peter, Kruzliak, Peter, Gaspar, Ludovit, Caprnda, Martin, Bendzala, Matej, Balaz, David, Oravec, Stanislav, Dukat, Andrej
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2013
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3878953/
https://www.ncbi.nlm.nih.gov/pubmed/24314230
http://dx.doi.org/10.1186/1476-511X-12-179
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author Sabaka, Peter
Kruzliak, Peter
Gaspar, Ludovit
Caprnda, Martin
Bendzala, Matej
Balaz, David
Oravec, Stanislav
Dukat, Andrej
author_facet Sabaka, Peter
Kruzliak, Peter
Gaspar, Ludovit
Caprnda, Martin
Bendzala, Matej
Balaz, David
Oravec, Stanislav
Dukat, Andrej
author_sort Sabaka, Peter
collection PubMed
description BACKGROUND: Majority of studies that focused on the influence of abdominal obesity on lipoprotein profile, were conducted in the fasting conditions. The effects of visceral fat accumulation on postprandial lipoprotein concentrations have not yet been studied in details. We therefore focused on the postprandial lipoprotein profile in otherwise healthy men and women with abdominal obesity and their comparison with the control group of volunteers with normal waist circumference. The concentration of lipoprotein classes and subclasses was measured before and 4 hours after a standard meal by linear polyacrylamide gel electrophoresis. RESULTS: A statistically significant postprandial rise in triacylglycerol concentration occurred in all subjects. VLDL increased 4 hours after meal in all subjects except the women with normal waist circumference. The concentration of large IDL particles increased in both non-obese men and women. In women with abdominal obesity, however, it decreased, while in obese men there was no statistically significant change. The concentration of small and medium-sized IDL particles decreased in all volunteers. Analyzing subclasses changes of large, medium-sized and small LDL particles we saw no significant shift in their concentrations except the subclass of large LDL particles, which decreased in men. Concentrations of medium and small HDL particles decreased postprandially in all volunteers with normal waist circumference. However, they remained unchanged in subjects with abdominal obesity. CONCLUSIONS: We observed significant postprandial changes of the lipoprotein profile, but the nature and extent of these changes depended on gender and presence of abdominal obesity.
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spelling pubmed-38789532014-01-03 Postprandial changes of lipoprotein profile: effect of abdominal obesity Sabaka, Peter Kruzliak, Peter Gaspar, Ludovit Caprnda, Martin Bendzala, Matej Balaz, David Oravec, Stanislav Dukat, Andrej Lipids Health Dis Research BACKGROUND: Majority of studies that focused on the influence of abdominal obesity on lipoprotein profile, were conducted in the fasting conditions. The effects of visceral fat accumulation on postprandial lipoprotein concentrations have not yet been studied in details. We therefore focused on the postprandial lipoprotein profile in otherwise healthy men and women with abdominal obesity and their comparison with the control group of volunteers with normal waist circumference. The concentration of lipoprotein classes and subclasses was measured before and 4 hours after a standard meal by linear polyacrylamide gel electrophoresis. RESULTS: A statistically significant postprandial rise in triacylglycerol concentration occurred in all subjects. VLDL increased 4 hours after meal in all subjects except the women with normal waist circumference. The concentration of large IDL particles increased in both non-obese men and women. In women with abdominal obesity, however, it decreased, while in obese men there was no statistically significant change. The concentration of small and medium-sized IDL particles decreased in all volunteers. Analyzing subclasses changes of large, medium-sized and small LDL particles we saw no significant shift in their concentrations except the subclass of large LDL particles, which decreased in men. Concentrations of medium and small HDL particles decreased postprandially in all volunteers with normal waist circumference. However, they remained unchanged in subjects with abdominal obesity. CONCLUSIONS: We observed significant postprandial changes of the lipoprotein profile, but the nature and extent of these changes depended on gender and presence of abdominal obesity. BioMed Central 2013-12-08 /pmc/articles/PMC3878953/ /pubmed/24314230 http://dx.doi.org/10.1186/1476-511X-12-179 Text en Copyright © 2013 Sabaka et al.; licensee BioMed Central Ltd. http://creativecommons.org/licenses/by/2.0 This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.
spellingShingle Research
Sabaka, Peter
Kruzliak, Peter
Gaspar, Ludovit
Caprnda, Martin
Bendzala, Matej
Balaz, David
Oravec, Stanislav
Dukat, Andrej
Postprandial changes of lipoprotein profile: effect of abdominal obesity
title Postprandial changes of lipoprotein profile: effect of abdominal obesity
title_full Postprandial changes of lipoprotein profile: effect of abdominal obesity
title_fullStr Postprandial changes of lipoprotein profile: effect of abdominal obesity
title_full_unstemmed Postprandial changes of lipoprotein profile: effect of abdominal obesity
title_short Postprandial changes of lipoprotein profile: effect of abdominal obesity
title_sort postprandial changes of lipoprotein profile: effect of abdominal obesity
topic Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3878953/
https://www.ncbi.nlm.nih.gov/pubmed/24314230
http://dx.doi.org/10.1186/1476-511X-12-179
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