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Experience with DPP-4 inhibitors in the management of patients with type 2 diabetes fasting during Ramadan

A large proportion of Muslim patients with type 2 diabetes mellitus (T2DM) elect to fast during the holy month of Ramadan. For these patients hypo- and hyperglycemia constitute two major complications associated with the profound changes in food pattern during the Ramadan fast, and efficacious treat...

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Autores principales: Schweizer, Anja, Halimi, Serge, Dejager, Sylvie
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Dove Medical Press 2013
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3878957/
https://www.ncbi.nlm.nih.gov/pubmed/24391442
http://dx.doi.org/10.2147/VHRM.S54585
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author Schweizer, Anja
Halimi, Serge
Dejager, Sylvie
author_facet Schweizer, Anja
Halimi, Serge
Dejager, Sylvie
author_sort Schweizer, Anja
collection PubMed
description A large proportion of Muslim patients with type 2 diabetes mellitus (T2DM) elect to fast during the holy month of Ramadan. For these patients hypo- and hyperglycemia constitute two major complications associated with the profound changes in food pattern during the Ramadan fast, and efficacious treatment options with a low risk of hypoglycemia are therefore needed to manage their T2DM as effectively and safely as possible. Dipeptidyl peptidase-4 (DPP-4) inhibitors modulate insulin and glucagon secretion in a glucose-dependent manner, and consequently a low propensity of hypoglycemia has consistently been reported across different patient populations with these agents. Promising data with DPP-4 inhibitors have now also started to emerge in patients with T2DM fasting during Ramadan. The objective of this review is to provide a comprehensive overview of the currently available evidence and potential role of DPP-4 inhibitors in the management of patients with T2DM fasting during Ramadan whose diabetes is treated with oral antidiabetic drugs, and to discuss the mechanistic basis for their beneficial effects in this setting.
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spelling pubmed-38789572014-01-03 Experience with DPP-4 inhibitors in the management of patients with type 2 diabetes fasting during Ramadan Schweizer, Anja Halimi, Serge Dejager, Sylvie Vasc Health Risk Manag Review A large proportion of Muslim patients with type 2 diabetes mellitus (T2DM) elect to fast during the holy month of Ramadan. For these patients hypo- and hyperglycemia constitute two major complications associated with the profound changes in food pattern during the Ramadan fast, and efficacious treatment options with a low risk of hypoglycemia are therefore needed to manage their T2DM as effectively and safely as possible. Dipeptidyl peptidase-4 (DPP-4) inhibitors modulate insulin and glucagon secretion in a glucose-dependent manner, and consequently a low propensity of hypoglycemia has consistently been reported across different patient populations with these agents. Promising data with DPP-4 inhibitors have now also started to emerge in patients with T2DM fasting during Ramadan. The objective of this review is to provide a comprehensive overview of the currently available evidence and potential role of DPP-4 inhibitors in the management of patients with T2DM fasting during Ramadan whose diabetes is treated with oral antidiabetic drugs, and to discuss the mechanistic basis for their beneficial effects in this setting. Dove Medical Press 2013-12-24 /pmc/articles/PMC3878957/ /pubmed/24391442 http://dx.doi.org/10.2147/VHRM.S54585 Text en © 2014 Schweizer et al. This work is published by Dove Medical Press Limited, and licensed under Creative Commons Attribution – Non Commercial (unported, v3.0) License The full terms of the License are available at http://creativecommons.org/licenses/by-nc/3.0/. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed.
spellingShingle Review
Schweizer, Anja
Halimi, Serge
Dejager, Sylvie
Experience with DPP-4 inhibitors in the management of patients with type 2 diabetes fasting during Ramadan
title Experience with DPP-4 inhibitors in the management of patients with type 2 diabetes fasting during Ramadan
title_full Experience with DPP-4 inhibitors in the management of patients with type 2 diabetes fasting during Ramadan
title_fullStr Experience with DPP-4 inhibitors in the management of patients with type 2 diabetes fasting during Ramadan
title_full_unstemmed Experience with DPP-4 inhibitors in the management of patients with type 2 diabetes fasting during Ramadan
title_short Experience with DPP-4 inhibitors in the management of patients with type 2 diabetes fasting during Ramadan
title_sort experience with dpp-4 inhibitors in the management of patients with type 2 diabetes fasting during ramadan
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3878957/
https://www.ncbi.nlm.nih.gov/pubmed/24391442
http://dx.doi.org/10.2147/VHRM.S54585
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