Targeting cell migration and the endoplasmic reticulum stress response with calmodulin antagonists: a clinically tested small molecule phenocopy of SEC62 gene silencing in human tumor cells

BACKGROUND: Tumor cells benefit from their ability to avoid apoptosis and invade other tissues. The endoplasmic reticulum (ER) membrane protein Sec62 is a key player in these processes. Sec62 is essential for cell migration and protects tumor cells against thapsigargin-induced ER stress, which are b...

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Detalles Bibliográficos
Autores principales: Linxweiler, Maximilian, Schorr, Stefan, Schäuble, Nico, Jung, Martin, Linxweiler, Johannes, Langer, Frank, Schäfers, Hans-Joachim, Cavalié, Adolfo, Zimmermann, Richard, Greiner, Markus
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2013
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3878975/
https://www.ncbi.nlm.nih.gov/pubmed/24304694
http://dx.doi.org/10.1186/1471-2407-13-574

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