A Multi-Scale Model of Hepcidin Promoter Regulation Reveals Factors Controlling Systemic Iron Homeostasis

Systemic iron homeostasis involves a negative feedback circuit in which the expression level of the peptide hormone hepcidin depends on and controls the iron blood levels. Hepcidin expression is regulated by the BMP6/SMAD and IL6/STAT signaling cascades. Deregulation of either pathway causes iron-re...

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Detalles Bibliográficos
Autores principales: Casanovas, Guillem, Banerji, Anashua, d'Alessio, Flavia, Muckenthaler, Martina U., Legewie, Stefan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2014
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3879105/
https://www.ncbi.nlm.nih.gov/pubmed/24391488
http://dx.doi.org/10.1371/journal.pcbi.1003421

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