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A calibrated agent-based computer model of stochastic cell dynamics in normal human colon crypts useful for in silico experiments
BACKGROUND: Normal colon crypts consist of stem cells, proliferating cells, and differentiated cells. Abnormal rates of proliferation and differentiation can initiate colon cancer. We have measured the variation in the number of each of these cell types in multiple crypts in normal human biopsy spec...
| Autores principales: | , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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BioMed Central
2013
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3879123/ https://www.ncbi.nlm.nih.gov/pubmed/24245614 http://dx.doi.org/10.1186/1742-4682-10-66 |