Replenish the source within: Rescuing tumor-infiltrating lymphocytes by double checkpoint blockade

We have recently reported that the PD-1 and CTLA4 signaling pathways are active in both effector and regulatory T cells, causing profound immune dysfunctions in the tumor microenvironment. In line with this notion, the dual blockade of PD-1- and CTLA4-conveyed signals may exert robust therapeutic ef...

Descripción completa

Detalles Bibliográficos
Autores principales: Duraiswamy, Jaikumar, Freeman, Gordon, Coukos, George
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Landes Bioscience 2013
Materias:
Author's View
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3879129/
https://www.ncbi.nlm.nih.gov/pubmed/24404420
http://dx.doi.org/10.4161/onci.25912
Descripción
Sumario:We have recently reported that the PD-1 and CTLA4 signaling pathways are active in both effector and regulatory T cells, causing profound immune dysfunctions in the tumor microenvironment. In line with this notion, the dual blockade of PD-1- and CTLA4-conveyed signals may exert robust therapeutic effects. Here, we discuss the mechanisms possibly underlying such a synergic interaction.

Ejemplares similares