Replenish the source within: Rescuing tumor-infiltrating lymphocytes by double checkpoint blockade

We have recently reported that the PD-1 and CTLA4 signaling pathways are active in both effector and regulatory T cells, causing profound immune dysfunctions in the tumor microenvironment. In line with this notion, the dual blockade of PD-1- and CTLA4-conveyed signals may exert robust therapeutic ef...

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Detalles Bibliográficos
Autores principales: Duraiswamy, Jaikumar, Freeman, Gordon, Coukos, George
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Landes Bioscience 2013
Materias:
Author's View
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3879129/
https://www.ncbi.nlm.nih.gov/pubmed/24404420
http://dx.doi.org/10.4161/onci.25912
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author Duraiswamy, Jaikumar
Freeman, Gordon
Coukos, George
author_facet Duraiswamy, Jaikumar
Freeman, Gordon
Coukos, George
author_sort Duraiswamy, Jaikumar
collection PubMed
description We have recently reported that the PD-1 and CTLA4 signaling pathways are active in both effector and regulatory T cells, causing profound immune dysfunctions in the tumor microenvironment. In line with this notion, the dual blockade of PD-1- and CTLA4-conveyed signals may exert robust therapeutic effects. Here, we discuss the mechanisms possibly underlying such a synergic interaction.
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spelling pubmed-38791292014-01-08 Replenish the source within: Rescuing tumor-infiltrating lymphocytes by double checkpoint blockade Duraiswamy, Jaikumar Freeman, Gordon Coukos, George Oncoimmunology Author's View We have recently reported that the PD-1 and CTLA4 signaling pathways are active in both effector and regulatory T cells, causing profound immune dysfunctions in the tumor microenvironment. In line with this notion, the dual blockade of PD-1- and CTLA4-conveyed signals may exert robust therapeutic effects. Here, we discuss the mechanisms possibly underlying such a synergic interaction. Landes Bioscience 2013-10-01 2013-08-02 /pmc/articles/PMC3879129/ /pubmed/24404420 http://dx.doi.org/10.4161/onci.25912 Text en Copyright © 2013 Landes Bioscience http://creativecommons.org/licenses/by-nc/3.0/ This is an open-access article licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported License. The article may be redistributed, reproduced, and reused for non-commercial purposes, provided the original source is properly cited.
spellingShingle Author's View
Duraiswamy, Jaikumar
Freeman, Gordon
Coukos, George
Replenish the source within: Rescuing tumor-infiltrating lymphocytes by double checkpoint blockade
title Replenish the source within: Rescuing tumor-infiltrating lymphocytes by double checkpoint blockade
title_full Replenish the source within: Rescuing tumor-infiltrating lymphocytes by double checkpoint blockade
title_fullStr Replenish the source within: Rescuing tumor-infiltrating lymphocytes by double checkpoint blockade
title_full_unstemmed Replenish the source within: Rescuing tumor-infiltrating lymphocytes by double checkpoint blockade
title_short Replenish the source within: Rescuing tumor-infiltrating lymphocytes by double checkpoint blockade
title_sort replenish the source within: rescuing tumor-infiltrating lymphocytes by double checkpoint blockade
topic Author's View
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3879129/
https://www.ncbi.nlm.nih.gov/pubmed/24404420
http://dx.doi.org/10.4161/onci.25912
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