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Replenish the source within: Rescuing tumor-infiltrating lymphocytes by double checkpoint blockade

We have recently reported that the PD-1 and CTLA4 signaling pathways are active in both effector and regulatory T cells, causing profound immune dysfunctions in the tumor microenvironment. In line with this notion, the dual blockade of PD-1- and CTLA4-conveyed signals may exert robust therapeutic ef...

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Detalles Bibliográficos
Autores principales:	Duraiswamy, Jaikumar, Freeman, Gordon, Coukos, George
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Landes Bioscience 2013
Materias:	Author's View
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3879129/ https://www.ncbi.nlm.nih.gov/pubmed/24404420 http://dx.doi.org/10.4161/onci.25912

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