Cargando…

A complex affair: Attraction and repulsion make occludin and ZO-1 function!

Tight junctions (TJs) are protein complexes comprised of claudins, which anchor them in the membrane and numerous cytosolic scaffolding proteins including MAGI, MUPP1, cingulin and members of the Zonula Occludens (ZO) family. Originally, their main function was thought to be as a paracellular barrie...

Descripción completa

Detalles Bibliográficos
Autores principales: Bewley, Maria C., Tash, Brian R., Tian, Fang, Flanagan, John M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Landes Bioscience 2013
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3879131/
https://www.ncbi.nlm.nih.gov/pubmed/24665376
http://dx.doi.org/10.4161/tisb.23496
_version_ 1782297923959128064
author Bewley, Maria C.
Tash, Brian R.
Tian, Fang
Flanagan, John M.
author_facet Bewley, Maria C.
Tash, Brian R.
Tian, Fang
Flanagan, John M.
author_sort Bewley, Maria C.
collection PubMed
description Tight junctions (TJs) are protein complexes comprised of claudins, which anchor them in the membrane and numerous cytosolic scaffolding proteins including MAGI, MUPP1, cingulin and members of the Zonula Occludens (ZO) family. Originally, their main function was thought to be as a paracellular barrier. More recently, however, additional roles in signal transduction, differentiation and proliferation have been reported. Dysregulation is associated with a wide range of disease states, including diabetic retinopathy, irritable bowel disease and some cancers. ZO proteins and occludin form a protein complex that appears to act as a master regulator of TJ assembly/disassembly. Recent studies have highlighted the structural character of the primary ZO-1:occludin interaction and identified regions on occludin that control association and disassociation of TJ in a phosphorylation-dependent manner. We hypothesize that regions within ZO-1 in the so-called U5 and U6 regions behave in a similar manner.
format Online
Article
Text
id pubmed-3879131
institution National Center for Biotechnology Information
language English
publishDate 2013
publisher Landes Bioscience
record_format MEDLINE/PubMed
spelling pubmed-38791312014-02-19 A complex affair: Attraction and repulsion make occludin and ZO-1 function! Bewley, Maria C. Tash, Brian R. Tian, Fang Flanagan, John M. Tissue Barriers Commentary Tight junctions (TJs) are protein complexes comprised of claudins, which anchor them in the membrane and numerous cytosolic scaffolding proteins including MAGI, MUPP1, cingulin and members of the Zonula Occludens (ZO) family. Originally, their main function was thought to be as a paracellular barrier. More recently, however, additional roles in signal transduction, differentiation and proliferation have been reported. Dysregulation is associated with a wide range of disease states, including diabetic retinopathy, irritable bowel disease and some cancers. ZO proteins and occludin form a protein complex that appears to act as a master regulator of TJ assembly/disassembly. Recent studies have highlighted the structural character of the primary ZO-1:occludin interaction and identified regions on occludin that control association and disassociation of TJ in a phosphorylation-dependent manner. We hypothesize that regions within ZO-1 in the so-called U5 and U6 regions behave in a similar manner. Landes Bioscience 2013-01-01 2013-01-01 /pmc/articles/PMC3879131/ /pubmed/24665376 http://dx.doi.org/10.4161/tisb.23496 Text en Copyright © 2013 Landes Bioscience http://creativecommons.org/licenses/by-nc/3.0/ This is an open-access article licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported License. The article may be redistributed, reproduced, and reused for non-commercial purposes, provided the original source is properly cited.
spellingShingle Commentary
Bewley, Maria C.
Tash, Brian R.
Tian, Fang
Flanagan, John M.
A complex affair: Attraction and repulsion make occludin and ZO-1 function!
title A complex affair: Attraction and repulsion make occludin and ZO-1 function!
title_full A complex affair: Attraction and repulsion make occludin and ZO-1 function!
title_fullStr A complex affair: Attraction and repulsion make occludin and ZO-1 function!
title_full_unstemmed A complex affair: Attraction and repulsion make occludin and ZO-1 function!
title_short A complex affair: Attraction and repulsion make occludin and ZO-1 function!
title_sort complex affair: attraction and repulsion make occludin and zo-1 function!
topic Commentary
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3879131/
https://www.ncbi.nlm.nih.gov/pubmed/24665376
http://dx.doi.org/10.4161/tisb.23496
work_keys_str_mv AT bewleymariac acomplexaffairattractionandrepulsionmakeoccludinandzo1function
AT tashbrianr acomplexaffairattractionandrepulsionmakeoccludinandzo1function
AT tianfang acomplexaffairattractionandrepulsionmakeoccludinandzo1function
AT flanaganjohnm acomplexaffairattractionandrepulsionmakeoccludinandzo1function
AT bewleymariac complexaffairattractionandrepulsionmakeoccludinandzo1function
AT tashbrianr complexaffairattractionandrepulsionmakeoccludinandzo1function
AT tianfang complexaffairattractionandrepulsionmakeoccludinandzo1function
AT flanaganjohnm complexaffairattractionandrepulsionmakeoccludinandzo1function