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Lifespan Extension Conferred by Endoplasmic Reticulum Secretory Pathway Deficiency Requires Induction of the Unfolded Protein Response

Cells respond to accumulation of misfolded proteins in the endoplasmic reticulum (ER) by activating the unfolded protein response (UPR) signaling pathway. The UPR restores ER homeostasis by degrading misfolded proteins, inhibiting translation, and increasing expression of chaperones that enhance ER...

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Detalles Bibliográficos
Autores principales:	Labunskyy, Vyacheslav M., Gerashchenko, Maxim V., Delaney, Joe R., Kaya, Alaattin, Kennedy, Brian K., Kaeberlein, Matt, Gladyshev, Vadim N.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2014
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3879150/ https://www.ncbi.nlm.nih.gov/pubmed/24391512 http://dx.doi.org/10.1371/journal.pgen.1004019

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