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Locking endothelial junctions blocks leukocyte extravasation, but not in all tissues
The passage of leukocytes across the blood vessel wall is a fundamental event in the inflammatory response. During the last decades, there has been significant progress in understanding the molecular mechanisms involved in leukocyte transmigration. However, it is still a matter of debate whether leu...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Landes Bioscience
2013
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3879176/ https://www.ncbi.nlm.nih.gov/pubmed/24665379 http://dx.doi.org/10.4161/tisb.23805 |
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author | Küppers, Verena Vestweber, Dietmar Schulte, Dörte |
author_facet | Küppers, Verena Vestweber, Dietmar Schulte, Dörte |
author_sort | Küppers, Verena |
collection | PubMed |
description | The passage of leukocytes across the blood vessel wall is a fundamental event in the inflammatory response. During the last decades, there has been significant progress in understanding the molecular mechanisms involved in leukocyte transmigration. However, it is still a matter of debate whether leukocytes migrate paracellularly or transcellularly through an endothelial cell layer. We could recently show that a VE-cadherin-α-catenin fusion protein locks endothelial junctions in the skin and strongly reduces leukocyte diapedesis in lung, skin and cremaster, establishing the paracellular route as the major transmigration pathway in these tissues. However, the homing of naïve lymphocytes into lymph nodes and extravasation of neutrophils in the inflamed peritoneum were not affected by VE-cadherin-α-catenin. This unexpected heterogeneity of the diapedesis process in different tissues as well as the complexity and dynamics of the cadherin-catenin complex in regulating endothelial junctions will be discussed. |
format | Online Article Text |
id | pubmed-3879176 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2013 |
publisher | Landes Bioscience |
record_format | MEDLINE/PubMed |
spelling | pubmed-38791762014-02-19 Locking endothelial junctions blocks leukocyte extravasation, but not in all tissues Küppers, Verena Vestweber, Dietmar Schulte, Dörte Tissue Barriers Commentary The passage of leukocytes across the blood vessel wall is a fundamental event in the inflammatory response. During the last decades, there has been significant progress in understanding the molecular mechanisms involved in leukocyte transmigration. However, it is still a matter of debate whether leukocytes migrate paracellularly or transcellularly through an endothelial cell layer. We could recently show that a VE-cadherin-α-catenin fusion protein locks endothelial junctions in the skin and strongly reduces leukocyte diapedesis in lung, skin and cremaster, establishing the paracellular route as the major transmigration pathway in these tissues. However, the homing of naïve lymphocytes into lymph nodes and extravasation of neutrophils in the inflamed peritoneum were not affected by VE-cadherin-α-catenin. This unexpected heterogeneity of the diapedesis process in different tissues as well as the complexity and dynamics of the cadherin-catenin complex in regulating endothelial junctions will be discussed. Landes Bioscience 2013-01-01 2013-01-01 /pmc/articles/PMC3879176/ /pubmed/24665379 http://dx.doi.org/10.4161/tisb.23805 Text en Copyright © 2013 Landes Bioscience http://creativecommons.org/licenses/by-nc/3.0/ This is an open-access article licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported License. The article may be redistributed, reproduced, and reused for non-commercial purposes, provided the original source is properly cited. |
spellingShingle | Commentary Küppers, Verena Vestweber, Dietmar Schulte, Dörte Locking endothelial junctions blocks leukocyte extravasation, but not in all tissues |
title | Locking endothelial junctions blocks leukocyte extravasation, but not in all tissues |
title_full | Locking endothelial junctions blocks leukocyte extravasation, but not in all tissues |
title_fullStr | Locking endothelial junctions blocks leukocyte extravasation, but not in all tissues |
title_full_unstemmed | Locking endothelial junctions blocks leukocyte extravasation, but not in all tissues |
title_short | Locking endothelial junctions blocks leukocyte extravasation, but not in all tissues |
title_sort | locking endothelial junctions blocks leukocyte extravasation, but not in all tissues |
topic | Commentary |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3879176/ https://www.ncbi.nlm.nih.gov/pubmed/24665379 http://dx.doi.org/10.4161/tisb.23805 |
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