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BAIAP2 Is Related to Emotional Modulation of Human Memory Strength
Memory performance is the result of many distinct mental processes, such as memory encoding, forgetting, and modulation of memory strength by emotional arousal. These processes, which are subserved by partly distinct molecular profiles, are not always amenable to direct observation. Therefore, compu...
Autores principales: | , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Public Library of Science
2014
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3879265/ https://www.ncbi.nlm.nih.gov/pubmed/24392092 http://dx.doi.org/10.1371/journal.pone.0083707 |
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author | Luksys, Gediminas Ackermann, Sandra Coynel, David Fastenrath, Matthias Gschwind, Leo Heck, Angela Rasch, Bjoern Spalek, Klara Vogler, Christian Papassotiropoulos, Andreas de Quervain, Dominique |
author_facet | Luksys, Gediminas Ackermann, Sandra Coynel, David Fastenrath, Matthias Gschwind, Leo Heck, Angela Rasch, Bjoern Spalek, Klara Vogler, Christian Papassotiropoulos, Andreas de Quervain, Dominique |
author_sort | Luksys, Gediminas |
collection | PubMed |
description | Memory performance is the result of many distinct mental processes, such as memory encoding, forgetting, and modulation of memory strength by emotional arousal. These processes, which are subserved by partly distinct molecular profiles, are not always amenable to direct observation. Therefore, computational models can be used to make inferences about specific mental processes and to study their genetic underpinnings. Here we combined a computational model-based analysis of memory-related processes with high density genetic information derived from a genome-wide study in healthy young adults. After identifying the best-fitting model for a verbal memory task and estimating the best-fitting individual cognitive parameters, we found a common variant in the gene encoding the brain-specific angiogenesis inhibitor 1-associated protein 2 (BAIAP2) that was related to the model parameter reflecting modulation of verbal memory strength by negative valence. We also observed an association between the same genetic variant and a similar emotional modulation phenotype in a different population performing a picture memory task. Furthermore, using functional neuroimaging we found robust genotype-dependent differences in activity of the parahippocampal cortex that were specifically related to successful memory encoding of negative versus neutral information. Finally, we analyzed cortical gene expression data of 193 deceased subjects and detected significant BAIAP2 genotype-dependent differences in BAIAP2 mRNA levels. Our findings suggest that model-based dissociation of specific cognitive parameters can improve the understanding of genetic underpinnings of human learning and memory. |
format | Online Article Text |
id | pubmed-3879265 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2014 |
publisher | Public Library of Science |
record_format | MEDLINE/PubMed |
spelling | pubmed-38792652014-01-03 BAIAP2 Is Related to Emotional Modulation of Human Memory Strength Luksys, Gediminas Ackermann, Sandra Coynel, David Fastenrath, Matthias Gschwind, Leo Heck, Angela Rasch, Bjoern Spalek, Klara Vogler, Christian Papassotiropoulos, Andreas de Quervain, Dominique PLoS One Research Article Memory performance is the result of many distinct mental processes, such as memory encoding, forgetting, and modulation of memory strength by emotional arousal. These processes, which are subserved by partly distinct molecular profiles, are not always amenable to direct observation. Therefore, computational models can be used to make inferences about specific mental processes and to study their genetic underpinnings. Here we combined a computational model-based analysis of memory-related processes with high density genetic information derived from a genome-wide study in healthy young adults. After identifying the best-fitting model for a verbal memory task and estimating the best-fitting individual cognitive parameters, we found a common variant in the gene encoding the brain-specific angiogenesis inhibitor 1-associated protein 2 (BAIAP2) that was related to the model parameter reflecting modulation of verbal memory strength by negative valence. We also observed an association between the same genetic variant and a similar emotional modulation phenotype in a different population performing a picture memory task. Furthermore, using functional neuroimaging we found robust genotype-dependent differences in activity of the parahippocampal cortex that were specifically related to successful memory encoding of negative versus neutral information. Finally, we analyzed cortical gene expression data of 193 deceased subjects and detected significant BAIAP2 genotype-dependent differences in BAIAP2 mRNA levels. Our findings suggest that model-based dissociation of specific cognitive parameters can improve the understanding of genetic underpinnings of human learning and memory. Public Library of Science 2014-01-02 /pmc/articles/PMC3879265/ /pubmed/24392092 http://dx.doi.org/10.1371/journal.pone.0083707 Text en © 2014 Luksys et al http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited. |
spellingShingle | Research Article Luksys, Gediminas Ackermann, Sandra Coynel, David Fastenrath, Matthias Gschwind, Leo Heck, Angela Rasch, Bjoern Spalek, Klara Vogler, Christian Papassotiropoulos, Andreas de Quervain, Dominique BAIAP2 Is Related to Emotional Modulation of Human Memory Strength |
title |
BAIAP2 Is Related to Emotional Modulation of Human Memory Strength |
title_full |
BAIAP2 Is Related to Emotional Modulation of Human Memory Strength |
title_fullStr |
BAIAP2 Is Related to Emotional Modulation of Human Memory Strength |
title_full_unstemmed |
BAIAP2 Is Related to Emotional Modulation of Human Memory Strength |
title_short |
BAIAP2 Is Related to Emotional Modulation of Human Memory Strength |
title_sort | baiap2 is related to emotional modulation of human memory strength |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3879265/ https://www.ncbi.nlm.nih.gov/pubmed/24392092 http://dx.doi.org/10.1371/journal.pone.0083707 |
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