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Antagonism of Bradykinin B2 Receptor Prevents Inflammatory Responses in Human Endothelial Cells by Quenching the NF-kB Pathway Activation
BACKGROUND: Bradykinin (BK) induces angiogenesis by promoting vessel permeability, growth and remodeling. This study aimed to demonstrate that the B2R antagonist, fasitibant, inhibits the BK pro-angiogenic effects. METHODOLOGY: We assesed the ability of fasibitant to antagonize the BK stimulation of...
Autores principales: | Terzuoli, Erika, Meini, Stefania, Cucchi, Paola, Catalani, Claudio, Cialdai, Cecilia, Maggi, Carlo Alberto, Giachetti, Antonio, Ziche, Marina, Donnini, Sandra |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Public Library of Science
2014
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3879294/ https://www.ncbi.nlm.nih.gov/pubmed/24392129 http://dx.doi.org/10.1371/journal.pone.0084358 |
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