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Systemic Simvastatin Rescues Retinal Ganglion Cells from Optic Nerve Injury Possibly through Suppression of Astroglial NF-κB Activation

Neuroinflammation is involved in the death of retinal ganglion cells (RGCs) after optic nerve injury. The purpose of this study was to determine whether systemic simvastatin can suppress neuroinflammation in the optic nerve and rescue RGCs after the optic nerve is crushed. Simvastatin or its vehicle...

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Detalles Bibliográficos
Autores principales:	Morishita, Seita, Oku, Hidehiro, Horie, Taeko, Tonari, Masahiro, Kida, Teruyo, Okubo, Akiko, Sugiyama, Tetsuya, Takai, Shinji, Hara, Hideaki, Ikeda, Tsunehiko
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2014
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3879303/ https://www.ncbi.nlm.nih.gov/pubmed/24392131 http://dx.doi.org/10.1371/journal.pone.0084387

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