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Antagonistic Interplay between Necdin and Bmi1 Controls Proliferation of Neural Precursor Cells in the Embryonic Mouse Neocortex
Neural precursor cells (NPCs) in the neocortex exhibit a high proliferation capacity during early embryonic development and give rise to cortical projection neurons after maturation. Necdin, a mammal-specific MAGE (melanoma antigen) family protein that possesses anti-mitotic and pro-survival activit...
Autores principales: | Minamide, Ryohei, Fujiwara, Kazushiro, Hasegawa, Koichi, Yoshikawa, Kazuaki |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Public Library of Science
2014
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3879318/ https://www.ncbi.nlm.nih.gov/pubmed/24392139 http://dx.doi.org/10.1371/journal.pone.0084460 |
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