Cargando…

Metabolomics Reveals a Role for the Chromatin-Binding Protein HMGN5 in Glutathione Metabolism

High mobility group nucleosome-binding protein 5 (HMGN5) is a chromatin architectural protein that binds specifically to nucleosomes and reduces the compaction of the chromatin fiber. The protein is present in most vertebrate tissues however the physiological function of this protein is unknown. To...

Descripción completa

Detalles Bibliográficos
Autores principales:	Ciappio, Eric D., Krausz, Kristopher W., Rochman, Mark, Furusawa, Takashi, Bonzo, Jessica A., Tessarollo, Lino, Gonzalez, Frank J., Bustin, Michael
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2014
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3879345/ https://www.ncbi.nlm.nih.gov/pubmed/24392144 http://dx.doi.org/10.1371/journal.pone.0084583

Ejemplares similares

Chromatin De-Compaction By The Nucleosomal Binding Protein HMGN5 Impairs Nuclear Sturdiness
por: Furusawa, Takashi, et al.
Publicado: (2015)

Biological Functions of HMGN Chromosomal Proteins
por: Nanduri, Ravikanth, et al.
Publicado: (2020)

HMGN proteins modulate chromatin regulatory sites and gene expression during activation of naïve B cells
por: Zhang, Shaofei, et al.
Publicado: (2016)

H3K27ac nucleosomes facilitate HMGN localization at regulatory sites to modulate chromatin binding of transcription factors
por: Zhang, Shaofei, et al.
Publicado: (2022)

Multiple epigenetic factors co-localize with HMGN proteins in A-compartment chromatin
por: He, Bing, et al.
Publicado: (2022)

Epigenetic regulation of white adipose tissue plasticity and energy metabolism by nucleosome binding HMGN proteins
por: Nanduri, Ravikanth, et al.
Publicado: (2022)

Effects of HMGN variants on the cellular transcription profile
por: Rochman, Mark, et al.
Publicado: (2011)

Binding of HMGN proteins to cell specific enhancers stabilizes cell identity
por: He, Bing, et al.
Publicado: (2018)

HMGN1 and 2 remodel core and linker histone tail domains within chromatin
por: Murphy, Kevin J., et al.
Publicado: (2017)

Functional compensation among HMGN variants modulates the DNase I hypersensitive sites at enhancers
por: Deng, Tao, et al.
Publicado: (2015)

Global Metabolomics Reveals Urinary Biomarkers of Breast Cancer in a MCF-7 Xenograft Mouse Model
por: Johnson, Caroline H., et al.
Publicado: (2013)

Nucleosome structural changes induced by binding of non-histone chromosomal proteins HMGN1 and HMGN2()
por: Shimahara, Hideto, et al.
Publicado: (2013)

Human HMGN1 and HMGN2 are not required for transcription-coupled DNA repair
por: Apelt, Katja, et al.
Publicado: (2020)

Trisomy of a Down Syndrome Critical Region Globally Amplifies Transcription via HMGN1 Overexpression
por: Mowery, Cody T., et al.
Publicado: (2018)

Interplay between H1 and HMGN epigenetically regulates OLIG1&2 expression and oligodendrocyte differentiation
por: Deng, Tao, et al.
Publicado: (2017)

HMGN1 Modulates Nucleosome Occupancy and DNase I Hypersensitivity at the CpG Island Promoters of Embryonic Stem Cells
por: Deng, Tao, et al.
Publicado: (2013)

HMGN2 represses gene transcription via interaction with transcription factors Lef-1 and Pitx2 during amelogenesis
por: Eliason, Steven, et al.
Publicado: (2022)

Maintenance of active chromatin states by HMGN2 is required for stem cell identity in a pluripotent stem cell model
por: Garza-Manero, Sylvia, et al.
Publicado: (2019)

Nucleosome-binding protein HMGN2 exhibits antitumor activity in oral squamous cell carcinoma
por: HU, ANKANG, et al.
Publicado: (2014)

Lysine succinylation on non-histone chromosomal protein HMG-17 (HMGN2) regulates nucleosomal DNA accessibility by disrupting the HMGN2–nucleosome association
por: Jing, Yihang, et al.
Publicado: (2021)

Metabolomic profiling of metoprolol hypertension treatment reveals altered gut microbiota-derived urinary metabolites
por: Brocker, Chad N., et al.
Publicado: (2020)

Exogenous HMGN2 inhibits the migration and invasion of osteosarcoma cell lines
por: Xu, Enjie, et al.
Publicado: (2020)

The Activation Of ATM Depends On Chromatin Interactions Occurring Prior To DNA-Damage Induction
por: Kim, Yong-Chul, et al.
Publicado: (2008)

Functional genomics of HMGN3a and SMARCAL1 in early mammalian embryogenesis
por: Uzun, Alper, et al.
Publicado: (2009)

Effect of HMGN2 on proliferation and apoptosis of MCF-7 breast cancer cells
por: Fan, Bo, et al.
Publicado: (2019)

Targeted Metabolomics of Serum Acylcarnitines Evaluates Hepatoprotective Effect of Wuzhi Tablet (Schisandra sphenanthera Extract) against Acute Acetaminophen Toxicity
por: Bi, Huichang, et al.
Publicado: (2013)

HMGN2, a new anti-tumor effector molecule of CD8(+) T cells
por: Su, Lin, et al.
Publicado: (2014)

Spatial and Temporal Expression of High-Mobility-Group Nucleosome-Binding (HMGN) Genes in Brain Areas Associated with Cognition in Individuals with Down Syndrome
por: Rodríguez-Ortiz, Alejandra, et al.
Publicado: (2021)

Site-specific modification and segmental isotope labelling of HMGN1 reveals long-range conformational perturbations caused by posttranslational modifications
por: Niederacher, Gerhard, et al.
Publicado: (2021)

Metabolomic analysis of spontaneous neutrophil apoptosis reveals the potential involvement of glutathione depletion
por: Yuyun, Xiong, et al.
Publicado: (2020)

HMGN1 and R848 Synergistically Activate Dendritic Cells Using Multiple Signaling Pathways
por: Alam, Md Masud, et al.
Publicado: (2018)

MicroRNA-140-5p regulates osteosarcoma chemoresistance by targeting HMGN5 and autophagy
por: Meng, Yichen, et al.
Publicado: (2017)

Shaking up the silence: consequences of HMGN1 antagonizing PRC2 in the Down syndrome brain
por: Farley, Sean J., et al.
Publicado: (2022)

Expression of HMGB1 and HMGN2 in gingival tissues, GCF and PICF of periodontitis patients and peri-implantitis
por: Xie, Ping, et al.
Publicado: (2011)

miR-488 inhibits cell growth and metastasis in renal cell carcinoma by targeting HMGN5
por: Wei, Xin, et al.
Publicado: (2018)

HMGN2 regulates non‐tuberculous mycobacteria survival via modulation of M1 macrophage polarization
por: Wang, Xinyuan, et al.
Publicado: (2019)

HMGN1 enhances CRISPR-directed dual-function A-to-G and C-to-G base editing
por: Yang, Chao, et al.
Publicado: (2023)

The growth hormone receptor interacts with transcriptional regulator HMGN1 upon GH-induced nuclear translocation
por: Jain, Lekha, et al.
Publicado: (2023)

Hepatocyte Nuclear Factor 4α (HNF4α) Plays a Controlling Role in Expression of the Retinoic Acid Receptor β (RARβ) Gene in Hepatocytes
por: Zolfaghari, Reza, et al.
Publicado: (2023)

HMGN5 Silencing Suppresses Cell Biological Progression via AKT/MAPK Pathway in Human Glioblastoma Cells
por: Ma, Quanfeng, et al.
Publicado: (2020)

Cannot write session to /tmp/vufind_sessions/sess_suv194bvvgshjdco1ns40kc7f4