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Host-Specific Enzyme-Substrate Interactions in SPM-1 Metallo-β-Lactamase Are Modulated by Second Sphere Residues

Pseudomonas aeruginosa is one of the most virulent and resistant non-fermenting Gram-negative pathogens in the clinic. Unfortunately, P. aeruginosa has acquired genes encoding metallo-β-lactamases (MβLs), enzymes able to hydrolyze most β-lactam antibiotics. SPM-1 is an MβL produced only by P. aerugi...

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Detalles Bibliográficos
Autores principales:	González, Lisandro J., Moreno, Diego M., Bonomo, Robert A., Vila, Alejandro J.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2014
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3879351/ https://www.ncbi.nlm.nih.gov/pubmed/24391494 http://dx.doi.org/10.1371/journal.ppat.1003817

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