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Clinical and Biochemical Correlates of Serum L-Ergothioneine Concentrations in Community-Dwelling Middle-Aged and Older Adults

BACKGROUND: Despite the increasing interest towards the biological role of L-ergothioneine, little is known about the serum concentrations of this unusual aminothiol in older adults. We addressed this issue in a representative sample of community-dwelling middle-aged and older adults. METHODS: Body...

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Autores principales: Sotgia, Salvatore, Zinellu, Angelo, Mangoni, Arduino A., Pintus, Gianfranco, Attia, John, Carru, Ciriaco, McEvoy, Mark
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2014
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3879362/
https://www.ncbi.nlm.nih.gov/pubmed/24392160
http://dx.doi.org/10.1371/journal.pone.0084918
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author Sotgia, Salvatore
Zinellu, Angelo
Mangoni, Arduino A.
Pintus, Gianfranco
Attia, John
Carru, Ciriaco
McEvoy, Mark
author_facet Sotgia, Salvatore
Zinellu, Angelo
Mangoni, Arduino A.
Pintus, Gianfranco
Attia, John
Carru, Ciriaco
McEvoy, Mark
author_sort Sotgia, Salvatore
collection PubMed
description BACKGROUND: Despite the increasing interest towards the biological role of L-ergothioneine, little is known about the serum concentrations of this unusual aminothiol in older adults. We addressed this issue in a representative sample of community-dwelling middle-aged and older adults. METHODS: Body mass index, estimated glomerular filtration rate, serum concentrations of L-ergothioneine, taurine, homocysteine, cysteine, glutathione, cysteinylglycine, and glutamylcysteine were evaluated in 439 subjects (age 55–85 years) randomly selected from the Hunter Community Study. RESULTS: Median L-ergothioneine concentration in the entire cohort was 1.01 IQR 0.78–1.33 µmol/L. Concentrations were not affected by gender (P = 0.41) or by presence of chronic medical conditions (P = 0.15). By considering only healthy subjects, we defined a reference interval for L-ergothioneine serum concentrations from 0.36 (90% CI 0.31–0.44) to 3.08 (90% CI 2.45–3.76) µmol/L. Using stepwise multiple linear regression analysis L-ergothioneine was negatively correlated with age (rpartial = −0.15; P = 0.0018) and with glutamylcysteine concentrations (rpartial = −0.13; P = 0.0063). CONCLUSIONS: A thorough analysis of serum L-ergothioneine concentrations was performed in a large group of community-dwelling middle-aged and older adults. Reference intervals were established. Age and glutamylcysteine were independently negatively associated with L-ergothioneine serum concentration.
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spelling pubmed-38793622014-01-03 Clinical and Biochemical Correlates of Serum L-Ergothioneine Concentrations in Community-Dwelling Middle-Aged and Older Adults Sotgia, Salvatore Zinellu, Angelo Mangoni, Arduino A. Pintus, Gianfranco Attia, John Carru, Ciriaco McEvoy, Mark PLoS One Research Article BACKGROUND: Despite the increasing interest towards the biological role of L-ergothioneine, little is known about the serum concentrations of this unusual aminothiol in older adults. We addressed this issue in a representative sample of community-dwelling middle-aged and older adults. METHODS: Body mass index, estimated glomerular filtration rate, serum concentrations of L-ergothioneine, taurine, homocysteine, cysteine, glutathione, cysteinylglycine, and glutamylcysteine were evaluated in 439 subjects (age 55–85 years) randomly selected from the Hunter Community Study. RESULTS: Median L-ergothioneine concentration in the entire cohort was 1.01 IQR 0.78–1.33 µmol/L. Concentrations were not affected by gender (P = 0.41) or by presence of chronic medical conditions (P = 0.15). By considering only healthy subjects, we defined a reference interval for L-ergothioneine serum concentrations from 0.36 (90% CI 0.31–0.44) to 3.08 (90% CI 2.45–3.76) µmol/L. Using stepwise multiple linear regression analysis L-ergothioneine was negatively correlated with age (rpartial = −0.15; P = 0.0018) and with glutamylcysteine concentrations (rpartial = −0.13; P = 0.0063). CONCLUSIONS: A thorough analysis of serum L-ergothioneine concentrations was performed in a large group of community-dwelling middle-aged and older adults. Reference intervals were established. Age and glutamylcysteine were independently negatively associated with L-ergothioneine serum concentration. Public Library of Science 2014-01-02 /pmc/articles/PMC3879362/ /pubmed/24392160 http://dx.doi.org/10.1371/journal.pone.0084918 Text en © 2014 Sotgia et al http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.
spellingShingle Research Article
Sotgia, Salvatore
Zinellu, Angelo
Mangoni, Arduino A.
Pintus, Gianfranco
Attia, John
Carru, Ciriaco
McEvoy, Mark
Clinical and Biochemical Correlates of Serum L-Ergothioneine Concentrations in Community-Dwelling Middle-Aged and Older Adults
title Clinical and Biochemical Correlates of Serum L-Ergothioneine Concentrations in Community-Dwelling Middle-Aged and Older Adults
title_full Clinical and Biochemical Correlates of Serum L-Ergothioneine Concentrations in Community-Dwelling Middle-Aged and Older Adults
title_fullStr Clinical and Biochemical Correlates of Serum L-Ergothioneine Concentrations in Community-Dwelling Middle-Aged and Older Adults
title_full_unstemmed Clinical and Biochemical Correlates of Serum L-Ergothioneine Concentrations in Community-Dwelling Middle-Aged and Older Adults
title_short Clinical and Biochemical Correlates of Serum L-Ergothioneine Concentrations in Community-Dwelling Middle-Aged and Older Adults
title_sort clinical and biochemical correlates of serum l-ergothioneine concentrations in community-dwelling middle-aged and older adults
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3879362/
https://www.ncbi.nlm.nih.gov/pubmed/24392160
http://dx.doi.org/10.1371/journal.pone.0084918
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