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Proteomic profiling of serum samples from chikungunya-infected patients provides insights into host response

BACKGROUND: Chikungunya is a highly debilitating febrile illness caused by Chikungunya virus, a single-stranded RNA virus, which is transmitted by Aedes aegypti or Aedes albopictus mosquito species. The pathogenesis and host responses in individuals infected with the chikungunya virus are not well u...

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Autores principales: Puttamallesh, Vinuth N, Sreenivasamurthy, Sreelakshmi K, Singh, Pradeep Kumar, Harsha, H C, Ganjiwale, Anjali, Broor, Shobha, Pandey, Akhilesh, Narayana, Jayasuryan, Prasad, T S Keshava
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer 2013
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3879382/
https://www.ncbi.nlm.nih.gov/pubmed/24124767
http://dx.doi.org/10.1186/1559-0275-10-14
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author Puttamallesh, Vinuth N
Sreenivasamurthy, Sreelakshmi K
Singh, Pradeep Kumar
Harsha, H C
Ganjiwale, Anjali
Broor, Shobha
Pandey, Akhilesh
Narayana, Jayasuryan
Prasad, T S Keshava
author_facet Puttamallesh, Vinuth N
Sreenivasamurthy, Sreelakshmi K
Singh, Pradeep Kumar
Harsha, H C
Ganjiwale, Anjali
Broor, Shobha
Pandey, Akhilesh
Narayana, Jayasuryan
Prasad, T S Keshava
author_sort Puttamallesh, Vinuth N
collection PubMed
description BACKGROUND: Chikungunya is a highly debilitating febrile illness caused by Chikungunya virus, a single-stranded RNA virus, which is transmitted by Aedes aegypti or Aedes albopictus mosquito species. The pathogenesis and host responses in individuals infected with the chikungunya virus are not well understood at the molecular level. We carried out proteomic profiling of serum samples from chikungunya patients in order to identify molecules associated with the host response to infection by this virus. RESULTS: Proteomic profiling of serum obtained from the infected individuals resulted in identification of 569 proteins. Of these, 63 proteins were found to be differentially expressed (≥ 2-fold) in patient as compared to control sera. These differentially expressed proteins were involved in various processes such as lipid metabolism, immune response, transport, signal transduction and apoptosis. CONCLUSIONS: This is the first report providing a global proteomic profile of serum samples from individuals infected with the chikungunya virus. Our data provide an insight into the proteins that are involved as host response factors during an infection. These proteins include clusterin, apolipoproteins and S100A family of proteins.
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spelling pubmed-38793822014-01-03 Proteomic profiling of serum samples from chikungunya-infected patients provides insights into host response Puttamallesh, Vinuth N Sreenivasamurthy, Sreelakshmi K Singh, Pradeep Kumar Harsha, H C Ganjiwale, Anjali Broor, Shobha Pandey, Akhilesh Narayana, Jayasuryan Prasad, T S Keshava Clin Proteomics Research BACKGROUND: Chikungunya is a highly debilitating febrile illness caused by Chikungunya virus, a single-stranded RNA virus, which is transmitted by Aedes aegypti or Aedes albopictus mosquito species. The pathogenesis and host responses in individuals infected with the chikungunya virus are not well understood at the molecular level. We carried out proteomic profiling of serum samples from chikungunya patients in order to identify molecules associated with the host response to infection by this virus. RESULTS: Proteomic profiling of serum obtained from the infected individuals resulted in identification of 569 proteins. Of these, 63 proteins were found to be differentially expressed (≥ 2-fold) in patient as compared to control sera. These differentially expressed proteins were involved in various processes such as lipid metabolism, immune response, transport, signal transduction and apoptosis. CONCLUSIONS: This is the first report providing a global proteomic profile of serum samples from individuals infected with the chikungunya virus. Our data provide an insight into the proteins that are involved as host response factors during an infection. These proteins include clusterin, apolipoproteins and S100A family of proteins. Springer 2013-10-14 /pmc/articles/PMC3879382/ /pubmed/24124767 http://dx.doi.org/10.1186/1559-0275-10-14 Text en Copyright © 2013 Puttamallesh et al.; licensee BioMed Central Ltd. http://creativecommons.org/licenses/by/2.0 This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research
Puttamallesh, Vinuth N
Sreenivasamurthy, Sreelakshmi K
Singh, Pradeep Kumar
Harsha, H C
Ganjiwale, Anjali
Broor, Shobha
Pandey, Akhilesh
Narayana, Jayasuryan
Prasad, T S Keshava
Proteomic profiling of serum samples from chikungunya-infected patients provides insights into host response
title Proteomic profiling of serum samples from chikungunya-infected patients provides insights into host response
title_full Proteomic profiling of serum samples from chikungunya-infected patients provides insights into host response
title_fullStr Proteomic profiling of serum samples from chikungunya-infected patients provides insights into host response
title_full_unstemmed Proteomic profiling of serum samples from chikungunya-infected patients provides insights into host response
title_short Proteomic profiling of serum samples from chikungunya-infected patients provides insights into host response
title_sort proteomic profiling of serum samples from chikungunya-infected patients provides insights into host response
topic Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3879382/
https://www.ncbi.nlm.nih.gov/pubmed/24124767
http://dx.doi.org/10.1186/1559-0275-10-14
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