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Antioxidant, anti-adipocyte differentiation, antitumor activity and anthelmintic activities against Anisakis simplex and Hymenolepis nana of yakuchinone A from Alpinia oxyphylla
BACKGROUND: Alpinia oxyphylla is a common remedy in traditional Chinese medicine. Yakuchinone A is a major constituent of A. oxyphylla and exhibits anti-inflammatory, antitumor, antibacterial, and gastric protective activities. METHODS: Antioxidant and antitumor characteristics of yakuchinone A in s...
Autores principales: | , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BioMed Central
2013
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3879407/ https://www.ncbi.nlm.nih.gov/pubmed/24070160 http://dx.doi.org/10.1186/1472-6882-13-237 |
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author | Lin, Rong-Jyh Yen, Chuan-Min Chou, Tzung-Han Chiang, Feng-Yu Wang, Guey-Horng Tseng, Ya-Ping Wang, Lin Huang, Ting-Wei Wang, Hui-Chuan Chan, Leong-Perng Ding, Hsiou-Yu Liang, Chia-Hua |
author_facet | Lin, Rong-Jyh Yen, Chuan-Min Chou, Tzung-Han Chiang, Feng-Yu Wang, Guey-Horng Tseng, Ya-Ping Wang, Lin Huang, Ting-Wei Wang, Hui-Chuan Chan, Leong-Perng Ding, Hsiou-Yu Liang, Chia-Hua |
author_sort | Lin, Rong-Jyh |
collection | PubMed |
description | BACKGROUND: Alpinia oxyphylla is a common remedy in traditional Chinese medicine. Yakuchinone A is a major constituent of A. oxyphylla and exhibits anti-inflammatory, antitumor, antibacterial, and gastric protective activities. METHODS: Antioxidant and antitumor characteristics of yakuchinone A in skin cancer cells as well as novel mechanisms for the inhibition of adipocyte differentiation, cestocidal activities against Hymenolepis nana adults, and nematocidal activities against Anisakis simplex larvae are investigated. RESULTS: Yakuchinone A presents the ability of the removal of DPPH·and ABTS(+) free radicals and inhibition of lipid peroxidation. Yakuchinone A suppresses intracellular lipid accumulation during adipocyte differentiation in 3 T3-L1 cells and the expressions of leptin and peroxisome proliferator-activated receptor γ (PPARγ). Yakuchinone A induces apoptosis and inhibits cell proliferation in skin cancer cells. The inhibition of cell growth by yakuchinone A is more significant for non-melanoma skin cancer (NMSC) cells than for melanoma (A375 and B16) and noncancerous (HaCaT and BNLCL2) cells. Treatment BCC cells with yakuchinone A shows down-regulation of Bcl-2, up-regulation of Bax, and an increase in cleavage poly (ADP-ribose) polymerase (PARP). This suggests that yakuchinone A induces BCC cells apoptosis through the Bcl-2-mediated signaling pathway. The anthelmintic activities of yakuchinone A for A. simplex are better than for H. nana. CONCLUSIONS: In this work, yakuchinone A exhibits antioxidative properties, anti-adipocyte differentiation, antitumor activity, and anthelmintic activities against A. simplex and H. nana. |
format | Online Article Text |
id | pubmed-3879407 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2013 |
publisher | BioMed Central |
record_format | MEDLINE/PubMed |
spelling | pubmed-38794072014-01-04 Antioxidant, anti-adipocyte differentiation, antitumor activity and anthelmintic activities against Anisakis simplex and Hymenolepis nana of yakuchinone A from Alpinia oxyphylla Lin, Rong-Jyh Yen, Chuan-Min Chou, Tzung-Han Chiang, Feng-Yu Wang, Guey-Horng Tseng, Ya-Ping Wang, Lin Huang, Ting-Wei Wang, Hui-Chuan Chan, Leong-Perng Ding, Hsiou-Yu Liang, Chia-Hua BMC Complement Altern Med Research Article BACKGROUND: Alpinia oxyphylla is a common remedy in traditional Chinese medicine. Yakuchinone A is a major constituent of A. oxyphylla and exhibits anti-inflammatory, antitumor, antibacterial, and gastric protective activities. METHODS: Antioxidant and antitumor characteristics of yakuchinone A in skin cancer cells as well as novel mechanisms for the inhibition of adipocyte differentiation, cestocidal activities against Hymenolepis nana adults, and nematocidal activities against Anisakis simplex larvae are investigated. RESULTS: Yakuchinone A presents the ability of the removal of DPPH·and ABTS(+) free radicals and inhibition of lipid peroxidation. Yakuchinone A suppresses intracellular lipid accumulation during adipocyte differentiation in 3 T3-L1 cells and the expressions of leptin and peroxisome proliferator-activated receptor γ (PPARγ). Yakuchinone A induces apoptosis and inhibits cell proliferation in skin cancer cells. The inhibition of cell growth by yakuchinone A is more significant for non-melanoma skin cancer (NMSC) cells than for melanoma (A375 and B16) and noncancerous (HaCaT and BNLCL2) cells. Treatment BCC cells with yakuchinone A shows down-regulation of Bcl-2, up-regulation of Bax, and an increase in cleavage poly (ADP-ribose) polymerase (PARP). This suggests that yakuchinone A induces BCC cells apoptosis through the Bcl-2-mediated signaling pathway. The anthelmintic activities of yakuchinone A for A. simplex are better than for H. nana. CONCLUSIONS: In this work, yakuchinone A exhibits antioxidative properties, anti-adipocyte differentiation, antitumor activity, and anthelmintic activities against A. simplex and H. nana. BioMed Central 2013-09-26 /pmc/articles/PMC3879407/ /pubmed/24070160 http://dx.doi.org/10.1186/1472-6882-13-237 Text en Copyright © 2013 Lin et al.; licensee BioMed Central Ltd. http://creativecommons.org/licenses/by/2.0 This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Research Article Lin, Rong-Jyh Yen, Chuan-Min Chou, Tzung-Han Chiang, Feng-Yu Wang, Guey-Horng Tseng, Ya-Ping Wang, Lin Huang, Ting-Wei Wang, Hui-Chuan Chan, Leong-Perng Ding, Hsiou-Yu Liang, Chia-Hua Antioxidant, anti-adipocyte differentiation, antitumor activity and anthelmintic activities against Anisakis simplex and Hymenolepis nana of yakuchinone A from Alpinia oxyphylla |
title | Antioxidant, anti-adipocyte differentiation, antitumor activity and anthelmintic
activities against Anisakis simplex and Hymenolepis nana of
yakuchinone A from Alpinia oxyphylla |
title_full | Antioxidant, anti-adipocyte differentiation, antitumor activity and anthelmintic
activities against Anisakis simplex and Hymenolepis nana of
yakuchinone A from Alpinia oxyphylla |
title_fullStr | Antioxidant, anti-adipocyte differentiation, antitumor activity and anthelmintic
activities against Anisakis simplex and Hymenolepis nana of
yakuchinone A from Alpinia oxyphylla |
title_full_unstemmed | Antioxidant, anti-adipocyte differentiation, antitumor activity and anthelmintic
activities against Anisakis simplex and Hymenolepis nana of
yakuchinone A from Alpinia oxyphylla |
title_short | Antioxidant, anti-adipocyte differentiation, antitumor activity and anthelmintic
activities against Anisakis simplex and Hymenolepis nana of
yakuchinone A from Alpinia oxyphylla |
title_sort | antioxidant, anti-adipocyte differentiation, antitumor activity and anthelmintic
activities against anisakis simplex and hymenolepis nana of
yakuchinone a from alpinia oxyphylla |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3879407/ https://www.ncbi.nlm.nih.gov/pubmed/24070160 http://dx.doi.org/10.1186/1472-6882-13-237 |
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