Inhibition of p38 Mitogen-activated Protein Kinase Impairs Influenza Virus-induced Primary and Secondary Host Gene Responses and Protects Mice from Lethal H5N1 Infection

Highly pathogenic avian influenza viruses (HPAIV) induce severe inflammation in poultry and men. One characteristic of HPAIV infections is the induction of a cytokine burst that strongly contributes to viral pathogenicity. This cell-intrinsic hypercytokinemia seems to involve hyperinduction of p38 m...

Descripción completa

Detalles Bibliográficos
Autores principales: Börgeling, Yvonne, Schmolke, Mirco, Viemann, Dorothee, Nordhoff, Carolin, Roth, Johannes, Ludwig, Stephan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Biochemistry and Molecular Biology 2014
Materias:
Molecular Bases of Disease
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3879537/
https://www.ncbi.nlm.nih.gov/pubmed/24189062
http://dx.doi.org/10.1074/jbc.M113.469239

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3879537/
https://www.ncbi.nlm.nih.gov/pubmed/24189062
http://dx.doi.org/10.1074/jbc.M113.469239

Ejemplares similares