Cargando…

Inhibition of p38 Mitogen-activated Protein Kinase Impairs Influenza Virus-induced Primary and Secondary Host Gene Responses and Protects Mice from Lethal H5N1 Infection

Highly pathogenic avian influenza viruses (HPAIV) induce severe inflammation in poultry and men. One characteristic of HPAIV infections is the induction of a cytokine burst that strongly contributes to viral pathogenicity. This cell-intrinsic hypercytokinemia seems to involve hyperinduction of p38 m...

Descripción completa

Detalles Bibliográficos
Autores principales:	Börgeling, Yvonne, Schmolke, Mirco, Viemann, Dorothee, Nordhoff, Carolin, Roth, Johannes, Ludwig, Stephan
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Society for Biochemistry and Molecular Biology 2014
Materias:	Molecular Bases of Disease
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3879537/ https://www.ncbi.nlm.nih.gov/pubmed/24189062 http://dx.doi.org/10.1074/jbc.M113.469239

Ejemplares similares

Protein Kinase Mitogen-activated Protein Kinase Kinase Kinase Kinase 4 (MAP4K4) Promotes Obesity-induced Hyperinsulinemia
por: Roth Flach, Rachel J., et al.
Publicado: (2016)

Influenza A Virus Inhibits Type I IFN Signaling via NF-κB-Dependent Induction of SOCS-3 Expression
por: Pauli, Eva-K., et al.
Publicado: (2008)

Calpain activation mediates microgravity-induced myocardial abnormalities in mice via p38 and ERK1/2 MAPK pathways
por: Liang, Liwen, et al.
Publicado: (2021)

Chronic wasting disease (CWD) prion strains evolve via adaptive diversification of conformers in hosts expressing prion protein polymorphisms
por: Duque Velásquez, Camilo, et al.
Publicado: (2020)

Proteolytic Activation of the Essential Parasitophorous Vacuole Cysteine Protease SERA6 Accompanies Malaria Parasite Egress from Its Host Erythrocyte
por: Ruecker, Andrea, et al.
Publicado: (2012)

TLR4 promoted endoplasmic reticulum stress induced inflammatory bowel disease via the activation of p38 MAPK pathway
por: Hu, Tian, et al.
Publicado: (2022)

Pathogenic LRRK2 requires secondary factors to induce cellular toxicity
por: Lobbestael, Evy, et al.
Publicado: (2020)

Disruption of the ATP-binding Cassette B7 (ABTM-1/ABCB7) Induces Oxidative Stress and Premature Cell Death in Caenorhabditis elegans
por: González-Cabo, Pilar, et al.
Publicado: (2011)

HIV and HCV Cooperatively Promote Hepatic Fibrogenesis via Induction of Reactive Oxygen Species and NFκB
por: Lin, Wenyu, et al.
Publicado: (2011)

Hepatitis B Virus X Protein Regulates Hepatic Glucose Homeostasis via Activation of Inducible Nitric Oxide Synthase
por: Shin, Hye-Jun, et al.
Publicado: (2011)

Disruption of a Novel Krüppel-like Transcription Factor p300-regulated Pathway for Insulin Biosynthesis Revealed by Studies of the c.-331 INS Mutation Found in Neonatal Diabetes Mellitus
por: Bonnefond, Amélie, et al.
Publicado: (2011)

Engineered Bivalent Ligands to Bias ErbB Receptor-mediated Signaling and Phenotypes
por: Jay, Steven M., et al.
Publicado: (2011)

Mitochondrial and Nuclear Genomic Responses to Loss of LRPPRC Expression
por: Gohil, Vishal M., et al.
Publicado: (2010)

The Legs at odd angles (Loa) Mutation in Cytoplasmic Dynein Ameliorates Mitochondrial Function in SOD1(G93A) Mouse Model for Motor Neuron Disease
por: El-Kadi, Ali Morsi, et al.
Publicado: (2010)

Understanding the Functional Interplay between Mammalian Mitochondrial Hsp70 Chaperone Machine Components
por: Goswami, Arvind Vittal, et al.
Publicado: (2010)

Bardet-Biedl Syndrome-associated Small GTPase ARL6 (BBS3) Functions at or near the Ciliary Gate and Modulates Wnt Signaling
por: Wiens, Cheryl J., et al.
Publicado: (2010)

Glutathione S-Transferase Omega 1 Activity Is Sufficient to Suppress Neurodegeneration in a Drosophila Model of Parkinson Disease
por: Kim, Kiyoung, et al.
Publicado: (2012)

The Role of the N-Domain in the ATPase Activity of the Mammalian AAA ATPase p97/VCP
por: Niwa, Hajime, et al.
Publicado: (2012)

Intrinsic Protein-Protein Interaction-mediated and Chaperonin-assisted Sequential Assembly of Stable Bardet-Biedl Syndrome Protein Complex, the BBSome
por: Zhang, Qihong, et al.
Publicado: (2012)

Expression in Drosophila of Tandem Amyloid β Peptides Provides Insights into Links between Aggregation and Neurotoxicity
por: Speretta, Elena, et al.
Publicado: (2012)

Tumors with Nonfunctional Retinoblastoma Protein Are Killed by Reduced γ-Tubulin Levels
por: Ehlén, Åsa, et al.
Publicado: (2012)

Expression of Mitochondrial Non-coding RNAs (ncRNAs) Is Modulated by High Risk Human Papillomavirus (HPV) Oncogenes
por: Villota, Claudio, et al.
Publicado: (2012)

Human Mutation within Per-Arnt-Sim (PAS) Domain-containing Protein Kinase (PASK) Causes Basal Insulin Hypersecretion
por: Semplici, Francesca, et al.
Publicado: (2011)

Neuronal Death Induced by Nanomolar Amyloid β Is Mediated by Primary Phagocytosis of Neurons by Microglia
por: Neniskyte, Urte, et al.
Publicado: (2011)

Increased Angiogenesis Protects against Adipose Hypoxia and Fibrosis in Metabolic Disease-resistant 11β-Hydroxysteroid Dehydrogenase Type 1 (HSD1)-deficient Mice
por: Michailidou, Zoi, et al.
Publicado: (2012)

Different 8-Hydroxyquinolines Protect Models of TDP-43 Protein, α-Synuclein, and Polyglutamine Proteotoxicity through Distinct Mechanisms
por: Tardiff, Daniel F., et al.
Publicado: (2012)

A Single Amino Acid Residue Constitutes the Third Dimerization Domain Essential for the Assembly and Function of the Tetrameric Polycystin-2 (TRPP2) Channel
por: Feng, Shuang, et al.
Publicado: (2011)

Dual Activity of Aminoarylthiazoles on the Trafficking and Gating Defects of the Cystic Fibrosis Transmembrane Conductance Regulator Chloride Channel Caused by Cystic Fibrosis Mutations
por: Pedemonte, Nicoletta, et al.
Publicado: (2011)

Molecular Basis for Transmission Barrier and Interference between Closely Related Prion Proteins in Yeast
por: Afanasieva, Evgenia G., et al.
Publicado: (2011)

The Chondroitin Sulfate A-binding Site of the VAR2CSA Protein Involves Multiple N-terminal Domains
por: Dahlbäck, Madeleine, et al.
Publicado: (2011)

Neurotoxic 43-kDa TAR DNA-binding Protein (TDP-43) Triggers Mitochondrion-dependent Programmed Cell Death in Yeast
por: Braun, Ralf J., et al.
Publicado: (2011)

The Novel PMCA2 Pump Mutation Tommy Impairs Cytosolic Calcium Clearance in Hair Cells and Links to Deafness in Mice
por: Bortolozzi, Mario, et al.
Publicado: (2010)

The Structural and Biochemical Characterization of Human RNase H2 Complex Reveals the Molecular Basis for Substrate Recognition and Aicardi-Goutières Syndrome Defects
por: Figiel, Małgorzata, et al.
Publicado: (2011)

Deoxyribonucleotide Metabolism in Cycling and Resting Human Fibroblasts with a Missense Mutation in p53R2, a Subunit of Ribonucleotide Reductase
por: Pontarin, Giovanna, et al.
Publicado: (2011)

No Reduction of Atherosclerosis in C-reactive Protein (CRP)-deficient Mice
por: Teupser, Daniel, et al.
Publicado: (2011)

Nephrocystin-4 Regulates Pyk2-induced Tyrosine Phosphorylation of Nephrocystin-1 to Control Targeting to Monocilia
por: Liebau, Max C., et al.
Publicado: (2011)

Methionine Oxidation Perturbs the Structural Core of the Prion Protein and Suggests a Generic Misfolding Pathway
por: Younan, Nadine D., et al.
Publicado: (2012)

Migfilin Protein Promotes Migration and Invasion in Human Glioma through Epidermal Growth Factor Receptor-mediated Phospholipase C-γ and STAT3 Protein Signaling Pathways
por: Ou, Yunwei, et al.
Publicado: (2012)

Counteracting Effects Operating on Src Homology 2 Domain-containing Protein-tyrosine Phosphatase 2 (SHP2) Function Drive Selection of the Recurrent Y62D and Y63C Substitutions in Noonan Syndrome
por: Martinelli, Simone, et al.
Publicado: (2012)

Sequestration of Sup35 by Aggregates of huntingtin Fragments Causes Toxicity of [PSI(+)] Yeast
por: Zhao, Xiaohong, et al.
Publicado: (2012)

Cannot write session to /tmp/vufind_sessions/sess_nlrdl9fdm9nitc71pu5nb4vcuq