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A Xanthine-Derivative K(+)-Channel Opener Protects against Serotonin-Induced Cardiomyocyte Hypertrophy via the Modulation of Protein Kinases

This study investigated whether KMUP-1, a xanthine-derivative K(+) channel opener, could prevent serotonin-induced hypertrophy in H9c2 cardiomyocytes via L-type Ca(2+) channels (LTCCs). Rat heart-derived H9c2 cells were incubated with serotonin (10 μM) for 4 days. The cell size increased by 155.5%,...

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Detalles Bibliográficos
Autores principales:	Kuo, Hsuan-Fu, Lai, Yan-Jie, Wu, Jung-Chou, Lee, Kun-Tai, Chu, Chih-Sheng, Chen, Ing-Jun, Wu, Jiunn-Ren, Wu, Bin-Nan
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Ivyspring International Publisher 2013
Materias:	Research Paper
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3879592/ https://www.ncbi.nlm.nih.gov/pubmed/24391452 http://dx.doi.org/10.7150/ijbs.7894

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