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Association of ABCC2 −24C>T Polymorphism with High-Dose Methotrexate Plasma Concentrations and Toxicities in Childhood Acute Lymphoblastic Leukemia

Methotrexate (MTX) is a key agent for the treatment of childhood acute lymphoblastic leukemia (ALL). Increased MTX plasma concentrations are associated with a higher risk of adverse drug effects. ATP-binding cassette subfamily C member 2 (ABCC2) is important for excretion of MTX and its toxic metabo...

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Detalles Bibliográficos
Autores principales:	Liu, Yan, Yin, You, Sheng, Qi, Lu, Xiaotong, Wang, Fang, Lin, Zhiyan, Tian, Huaiping, Xu, Ajing, Zhang, Jian
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2014
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3880259/ https://www.ncbi.nlm.nih.gov/pubmed/24404132 http://dx.doi.org/10.1371/journal.pone.0082681

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