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Rapamycin Ameliorates Inflammation and Fibrosis in the Early Phase of Cirrhotic Portal Hypertension in Rats through Inhibition of mTORC1 but Not mTORC2

OBJECTIVE: Hepatic stellate cells (HSCs) transdifferentiation and subsequent inflammation are important pathological processes involved in the formation of cirrhotic portal hypertension. This study characterizes the pathogenetic mechanisms leading to cholestatic liver fibrosis and portal hypertensio...

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Detalles Bibliográficos
Autores principales:	Wang, Weijie, Yan, Jiqi, Wang, Huakai, Shi, Minmin, Zhang, Mingjun, Yang, Weiping, Peng, Chenghong, Li, Hongwei
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2014
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3880276/ https://www.ncbi.nlm.nih.gov/pubmed/24404143 http://dx.doi.org/10.1371/journal.pone.0083908

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