Targeting of GFP-Cre to the Mouse Cyp11a1 Locus Both Drives Cre Recombinase Expression in Steroidogenic Cells and Permits Generation of Cyp11a1 Knock Out Mice

To permit conditional gene targeting of floxed alleles in steroidogenic cell-types we have generated a transgenic mouse line that expresses Cre Recombinase under the regulation of the endogenous Cytochrome P450 side chain cleavage enzyme (Cyp11a1) promoter. Mice Carrying the Cyp11a1-GC (GFP-Cre) all...

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Detalles Bibliográficos
Autores principales: O'Hara, Laura, York, Jean Philippe, Zhang, Pumin, Smith, Lee B.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2014
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3880310/
https://www.ncbi.nlm.nih.gov/pubmed/24404170
http://dx.doi.org/10.1371/journal.pone.0084541

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3880310/
https://www.ncbi.nlm.nih.gov/pubmed/24404170
http://dx.doi.org/10.1371/journal.pone.0084541

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