Cargando…

Essential role of axonal VGSC inactivation in time-dependent deceleration and unreliability of spike propagation at cerebellar Purkinje cells

BACKGROUND: The output of the neuronal digital spikes is fulfilled by axonal propagation and synaptic transmission to influence postsynaptic cells. Similar to synaptic transmission, spike propagation on the axon is not secure, especially in cerebellar Purkinje cells whose spiking rate is high. The c...

Descripción completa

Detalles Bibliográficos
Autores principales: Yang, Zhilai, Gu, Erwei, Lu, Xianfu, Wang, Jin-Hui
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2014
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3880351/
https://www.ncbi.nlm.nih.gov/pubmed/24382121
http://dx.doi.org/10.1186/1756-6606-7-1
_version_ 1782298077400399872
author Yang, Zhilai
Gu, Erwei
Lu, Xianfu
Wang, Jin-Hui
author_facet Yang, Zhilai
Gu, Erwei
Lu, Xianfu
Wang, Jin-Hui
author_sort Yang, Zhilai
collection PubMed
description BACKGROUND: The output of the neuronal digital spikes is fulfilled by axonal propagation and synaptic transmission to influence postsynaptic cells. Similar to synaptic transmission, spike propagation on the axon is not secure, especially in cerebellar Purkinje cells whose spiking rate is high. The characteristics, mechanisms and physiological impacts of propagation deceleration and infidelity remain elusive. The spike propagation is presumably initiated by local currents that raise membrane potential to the threshold of activating voltage-gated sodium channels (VGSC). RESULTS: We have investigated the natures of spike propagation and the role of VGSCs in this process by recording spikes simultaneously on the somata and axonal terminals of Purkinje cells in cerebellar slices. The velocity and fidelity of spike propagation decreased during long-lasting spikes, to which the velocity change was more sensitive than fidelity change. These time-dependent deceleration and infidelity of spike propagation were improved by facilitating axonal VGSC reactivation, and worsen by intensifying VGSC inactivation. CONCLUSION: Our studies indicate that the functional status of axonal VGSCs is essential to influencing the velocity and fidelity of spike propagation.
format Online
Article
Text
id pubmed-3880351
institution National Center for Biotechnology Information
language English
publishDate 2014
publisher BioMed Central
record_format MEDLINE/PubMed
spelling pubmed-38803512014-01-04 Essential role of axonal VGSC inactivation in time-dependent deceleration and unreliability of spike propagation at cerebellar Purkinje cells Yang, Zhilai Gu, Erwei Lu, Xianfu Wang, Jin-Hui Mol Brain Research BACKGROUND: The output of the neuronal digital spikes is fulfilled by axonal propagation and synaptic transmission to influence postsynaptic cells. Similar to synaptic transmission, spike propagation on the axon is not secure, especially in cerebellar Purkinje cells whose spiking rate is high. The characteristics, mechanisms and physiological impacts of propagation deceleration and infidelity remain elusive. The spike propagation is presumably initiated by local currents that raise membrane potential to the threshold of activating voltage-gated sodium channels (VGSC). RESULTS: We have investigated the natures of spike propagation and the role of VGSCs in this process by recording spikes simultaneously on the somata and axonal terminals of Purkinje cells in cerebellar slices. The velocity and fidelity of spike propagation decreased during long-lasting spikes, to which the velocity change was more sensitive than fidelity change. These time-dependent deceleration and infidelity of spike propagation were improved by facilitating axonal VGSC reactivation, and worsen by intensifying VGSC inactivation. CONCLUSION: Our studies indicate that the functional status of axonal VGSCs is essential to influencing the velocity and fidelity of spike propagation. BioMed Central 2014-01-02 /pmc/articles/PMC3880351/ /pubmed/24382121 http://dx.doi.org/10.1186/1756-6606-7-1 Text en Copyright © 2014 Yang et al.; licensee BioMed Central Ltd. http://creativecommons.org/licenses/by/2.0 This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.
spellingShingle Research
Yang, Zhilai
Gu, Erwei
Lu, Xianfu
Wang, Jin-Hui
Essential role of axonal VGSC inactivation in time-dependent deceleration and unreliability of spike propagation at cerebellar Purkinje cells
title Essential role of axonal VGSC inactivation in time-dependent deceleration and unreliability of spike propagation at cerebellar Purkinje cells
title_full Essential role of axonal VGSC inactivation in time-dependent deceleration and unreliability of spike propagation at cerebellar Purkinje cells
title_fullStr Essential role of axonal VGSC inactivation in time-dependent deceleration and unreliability of spike propagation at cerebellar Purkinje cells
title_full_unstemmed Essential role of axonal VGSC inactivation in time-dependent deceleration and unreliability of spike propagation at cerebellar Purkinje cells
title_short Essential role of axonal VGSC inactivation in time-dependent deceleration and unreliability of spike propagation at cerebellar Purkinje cells
title_sort essential role of axonal vgsc inactivation in time-dependent deceleration and unreliability of spike propagation at cerebellar purkinje cells
topic Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3880351/
https://www.ncbi.nlm.nih.gov/pubmed/24382121
http://dx.doi.org/10.1186/1756-6606-7-1
work_keys_str_mv AT yangzhilai essentialroleofaxonalvgscinactivationintimedependentdecelerationandunreliabilityofspikepropagationatcerebellarpurkinjecells
AT guerwei essentialroleofaxonalvgscinactivationintimedependentdecelerationandunreliabilityofspikepropagationatcerebellarpurkinjecells
AT luxianfu essentialroleofaxonalvgscinactivationintimedependentdecelerationandunreliabilityofspikepropagationatcerebellarpurkinjecells
AT wangjinhui essentialroleofaxonalvgscinactivationintimedependentdecelerationandunreliabilityofspikepropagationatcerebellarpurkinjecells