Stable insulin secreting ducts formed by reprogramming of cells in the liver using a three gene cocktail and a PPAR agonist

With the long term aim of developing a new type of therapy for diabetes, we have investigated the reprogramming of liver cells in normal mice towards a pancreatic phenotype using the gene combination Pdx1, Ngn3, MafA. CD1 mice were rendered diabetic with streptozotocin and given a single dose of Ad-...

Descripción completa

Detalles Bibliográficos
Autores principales: Banga, Anannya, Greder, Lucas V., Dutton, James R., Slack, Jonathan M.W.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2013
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3880604/
https://www.ncbi.nlm.nih.gov/pubmed/24089243
http://dx.doi.org/10.1038/gt.2013.50

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3880604/
https://www.ncbi.nlm.nih.gov/pubmed/24089243
http://dx.doi.org/10.1038/gt.2013.50

Ejemplares similares