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Stable insulin secreting ducts formed by reprogramming of cells in the liver using a three gene cocktail and a PPAR agonist
With the long term aim of developing a new type of therapy for diabetes, we have investigated the reprogramming of liver cells in normal mice towards a pancreatic phenotype using the gene combination Pdx1, Ngn3, MafA. CD1 mice were rendered diabetic with streptozotocin and given a single dose of Ad-...
| Autores principales: | , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
2013
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3880604/ https://www.ncbi.nlm.nih.gov/pubmed/24089243 http://dx.doi.org/10.1038/gt.2013.50 |