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Serotonin Syndrome after Sertraline Overdose in a Child: A Case Report
Serotonin syndrome is a potentially life-threatening drug effect. It may be misdiagnosed because it has mostly been reported in adults. Case Report. An 8-year-old girl with behavioral problems and medicated with risperidone and sertraline was admitted in the emergency department after she had taken...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Hindawi Publishing Corporation
2013
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3880707/ https://www.ncbi.nlm.nih.gov/pubmed/24455378 http://dx.doi.org/10.1155/2013/897902 |
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author | Grenha, Joana Garrido, Ana Brito, Hernani Oliveira, Maria José Santos, Fátima |
author_facet | Grenha, Joana Garrido, Ana Brito, Hernani Oliveira, Maria José Santos, Fátima |
author_sort | Grenha, Joana |
collection | PubMed |
description | Serotonin syndrome is a potentially life-threatening drug effect. It may be misdiagnosed because it has mostly been reported in adults. Case Report. An 8-year-old girl with behavioral problems and medicated with risperidone and sertraline was admitted in the emergency department after she had taken voluntarily 1500 mg of sertraline (50 mg/kg). At admission, she had marked agitation, visual hallucinations, diaphoresis, flushing, and tremor. She had fever and periods of hypertension. She also showed generalized rigidity and involuntary movements. She was treated with fluids and iv diazepam, midazolam, clemastine, and biperiden. As the patient presented a severe insomnia and a progressive rhabdomyolysis, she was transferred to pediatric intensive care unit (ICU), where she was under treatment with cyproheptadine, mechanical ventilation, and muscular paralysis for 11 days. She was discharged from hospital a few days later with no neurological sequelae. Conclusions. Serotonin syndrome is still not well recognized by physicians. In our patient, the diagnosis was made early due to the history of overdose with serotonin reuptake inhibitors and the triad of mental, neurological, and autonomic signs. Parents must be educated to prevent children from having free access to drugs, avoiding self-medication or overdose. |
format | Online Article Text |
id | pubmed-3880707 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2013 |
publisher | Hindawi Publishing Corporation |
record_format | MEDLINE/PubMed |
spelling | pubmed-38807072014-01-20 Serotonin Syndrome after Sertraline Overdose in a Child: A Case Report Grenha, Joana Garrido, Ana Brito, Hernani Oliveira, Maria José Santos, Fátima Case Rep Pediatr Case Report Serotonin syndrome is a potentially life-threatening drug effect. It may be misdiagnosed because it has mostly been reported in adults. Case Report. An 8-year-old girl with behavioral problems and medicated with risperidone and sertraline was admitted in the emergency department after she had taken voluntarily 1500 mg of sertraline (50 mg/kg). At admission, she had marked agitation, visual hallucinations, diaphoresis, flushing, and tremor. She had fever and periods of hypertension. She also showed generalized rigidity and involuntary movements. She was treated with fluids and iv diazepam, midazolam, clemastine, and biperiden. As the patient presented a severe insomnia and a progressive rhabdomyolysis, she was transferred to pediatric intensive care unit (ICU), where she was under treatment with cyproheptadine, mechanical ventilation, and muscular paralysis for 11 days. She was discharged from hospital a few days later with no neurological sequelae. Conclusions. Serotonin syndrome is still not well recognized by physicians. In our patient, the diagnosis was made early due to the history of overdose with serotonin reuptake inhibitors and the triad of mental, neurological, and autonomic signs. Parents must be educated to prevent children from having free access to drugs, avoiding self-medication or overdose. Hindawi Publishing Corporation 2013 2013-12-19 /pmc/articles/PMC3880707/ /pubmed/24455378 http://dx.doi.org/10.1155/2013/897902 Text en Copyright © 2013 Joana Grenha et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Case Report Grenha, Joana Garrido, Ana Brito, Hernani Oliveira, Maria José Santos, Fátima Serotonin Syndrome after Sertraline Overdose in a Child: A Case Report |
title | Serotonin Syndrome after Sertraline Overdose in a Child: A Case Report |
title_full | Serotonin Syndrome after Sertraline Overdose in a Child: A Case Report |
title_fullStr | Serotonin Syndrome after Sertraline Overdose in a Child: A Case Report |
title_full_unstemmed | Serotonin Syndrome after Sertraline Overdose in a Child: A Case Report |
title_short | Serotonin Syndrome after Sertraline Overdose in a Child: A Case Report |
title_sort | serotonin syndrome after sertraline overdose in a child: a case report |
topic | Case Report |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3880707/ https://www.ncbi.nlm.nih.gov/pubmed/24455378 http://dx.doi.org/10.1155/2013/897902 |
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