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Protective Effect of Theaflavin on Erythrocytes Subjected to In Vitro Oxidative Stress
Antioxidant and free radical scavenging effect of black tea theaflavins has been shown in many epidemiological studies. In the present work we report the protective mechanism of tea theaflavins on biomarkers of oxidative stress, which are elevated during stress conditions. We hereby report the in vi...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Hindawi Publishing Corporation
2013
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3880739/ https://www.ncbi.nlm.nih.gov/pubmed/24455262 http://dx.doi.org/10.1155/2013/649759 |
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author | Fatima, Mahejabeen Kesharwani, Rajesh Kumar Misra, Krishna Rizvi, Syed Ibrahim |
author_facet | Fatima, Mahejabeen Kesharwani, Rajesh Kumar Misra, Krishna Rizvi, Syed Ibrahim |
author_sort | Fatima, Mahejabeen |
collection | PubMed |
description | Antioxidant and free radical scavenging effect of black tea theaflavins has been shown in many epidemiological studies. In the present work we report the protective mechanism of tea theaflavins on biomarkers of oxidative stress, which are elevated during stress conditions. We hereby report the in vitro effect of theaflavins on erythrocyte malondialdehyde (MDA), intracellular reduced glutathione (GSH), and plasma membrane redox system (PMRS) of rats. The effect of theaflavin on PMRS has also been validated through an in silico docking simulation study using Molegro Virtual Docker (MVD). We report that theaflavins show significant protection to erythrocyte against oxidative stress induced by tert-butyl hydroperoxide (t-BHP). The findings suggest a possible protective role of theaflavins as antioxidant. |
format | Online Article Text |
id | pubmed-3880739 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2013 |
publisher | Hindawi Publishing Corporation |
record_format | MEDLINE/PubMed |
spelling | pubmed-38807392014-01-19 Protective Effect of Theaflavin on Erythrocytes Subjected to In Vitro Oxidative Stress Fatima, Mahejabeen Kesharwani, Rajesh Kumar Misra, Krishna Rizvi, Syed Ibrahim Biochem Res Int Research Article Antioxidant and free radical scavenging effect of black tea theaflavins has been shown in many epidemiological studies. In the present work we report the protective mechanism of tea theaflavins on biomarkers of oxidative stress, which are elevated during stress conditions. We hereby report the in vitro effect of theaflavins on erythrocyte malondialdehyde (MDA), intracellular reduced glutathione (GSH), and plasma membrane redox system (PMRS) of rats. The effect of theaflavin on PMRS has also been validated through an in silico docking simulation study using Molegro Virtual Docker (MVD). We report that theaflavins show significant protection to erythrocyte against oxidative stress induced by tert-butyl hydroperoxide (t-BHP). The findings suggest a possible protective role of theaflavins as antioxidant. Hindawi Publishing Corporation 2013 2013-12-21 /pmc/articles/PMC3880739/ /pubmed/24455262 http://dx.doi.org/10.1155/2013/649759 Text en Copyright © 2013 Mahejabeen Fatima et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Research Article Fatima, Mahejabeen Kesharwani, Rajesh Kumar Misra, Krishna Rizvi, Syed Ibrahim Protective Effect of Theaflavin on Erythrocytes Subjected to In Vitro Oxidative Stress |
title | Protective Effect of Theaflavin on Erythrocytes Subjected to In Vitro Oxidative Stress |
title_full | Protective Effect of Theaflavin on Erythrocytes Subjected to In Vitro Oxidative Stress |
title_fullStr | Protective Effect of Theaflavin on Erythrocytes Subjected to In Vitro Oxidative Stress |
title_full_unstemmed | Protective Effect of Theaflavin on Erythrocytes Subjected to In Vitro Oxidative Stress |
title_short | Protective Effect of Theaflavin on Erythrocytes Subjected to In Vitro Oxidative Stress |
title_sort | protective effect of theaflavin on erythrocytes subjected to in vitro oxidative stress |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3880739/ https://www.ncbi.nlm.nih.gov/pubmed/24455262 http://dx.doi.org/10.1155/2013/649759 |
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