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Therapeutic Implications of Immunogenic Cell Death in Human Cancer
Dendritic cells (DCs) are central to the adoptive immune response, and their function is regulated by diverse signals in a context-specific manner. Different DCs have been described in physiologic conditions, inflammation, and cancer, prompting a series of questions on how adoptive immune responses,...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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Frontiers Media S.A.
2014
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3880935/ https://www.ncbi.nlm.nih.gov/pubmed/24432020 http://dx.doi.org/10.3389/fimmu.2013.00503 |
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author | Palombo, Fabio Focaccetti, Chiara Barnaba, Vincenzo |
author_facet | Palombo, Fabio Focaccetti, Chiara Barnaba, Vincenzo |
author_sort | Palombo, Fabio |
collection | PubMed |
description | Dendritic cells (DCs) are central to the adoptive immune response, and their function is regulated by diverse signals in a context-specific manner. Different DCs have been described in physiologic conditions, inflammation, and cancer, prompting a series of questions on how adoptive immune responses, or tolerance, develop against tumors. Increasing evidence suggests that tumor treatments induce a dramatic change on tumor-infiltrating lymphocytes and, in particular, on some DC subtypes. In this review, we summarize the latest evidence on the role of DCs in cancer and preliminary evidence on chemotherapy-associated antigens identified in human cancers. |
format | Online Article Text |
id | pubmed-3880935 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2014 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-38809352014-01-15 Therapeutic Implications of Immunogenic Cell Death in Human Cancer Palombo, Fabio Focaccetti, Chiara Barnaba, Vincenzo Front Immunol Immunology Dendritic cells (DCs) are central to the adoptive immune response, and their function is regulated by diverse signals in a context-specific manner. Different DCs have been described in physiologic conditions, inflammation, and cancer, prompting a series of questions on how adoptive immune responses, or tolerance, develop against tumors. Increasing evidence suggests that tumor treatments induce a dramatic change on tumor-infiltrating lymphocytes and, in particular, on some DC subtypes. In this review, we summarize the latest evidence on the role of DCs in cancer and preliminary evidence on chemotherapy-associated antigens identified in human cancers. Frontiers Media S.A. 2014-01-06 /pmc/articles/PMC3880935/ /pubmed/24432020 http://dx.doi.org/10.3389/fimmu.2013.00503 Text en Copyright © 2014 Palombo, Focaccetti and Barnaba. http://creativecommons.org/licenses/by/3.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Immunology Palombo, Fabio Focaccetti, Chiara Barnaba, Vincenzo Therapeutic Implications of Immunogenic Cell Death in Human Cancer |
title | Therapeutic Implications of Immunogenic Cell Death in Human Cancer |
title_full | Therapeutic Implications of Immunogenic Cell Death in Human Cancer |
title_fullStr | Therapeutic Implications of Immunogenic Cell Death in Human Cancer |
title_full_unstemmed | Therapeutic Implications of Immunogenic Cell Death in Human Cancer |
title_short | Therapeutic Implications of Immunogenic Cell Death in Human Cancer |
title_sort | therapeutic implications of immunogenic cell death in human cancer |
topic | Immunology |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3880935/ https://www.ncbi.nlm.nih.gov/pubmed/24432020 http://dx.doi.org/10.3389/fimmu.2013.00503 |
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