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Therapeutic Implications of Immunogenic Cell Death in Human Cancer

Dendritic cells (DCs) are central to the adoptive immune response, and their function is regulated by diverse signals in a context-specific manner. Different DCs have been described in physiologic conditions, inflammation, and cancer, prompting a series of questions on how adoptive immune responses,...

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Detalles Bibliográficos
Autores principales: Palombo, Fabio, Focaccetti, Chiara, Barnaba, Vincenzo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2014
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3880935/
https://www.ncbi.nlm.nih.gov/pubmed/24432020
http://dx.doi.org/10.3389/fimmu.2013.00503
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author Palombo, Fabio
Focaccetti, Chiara
Barnaba, Vincenzo
author_facet Palombo, Fabio
Focaccetti, Chiara
Barnaba, Vincenzo
author_sort Palombo, Fabio
collection PubMed
description Dendritic cells (DCs) are central to the adoptive immune response, and their function is regulated by diverse signals in a context-specific manner. Different DCs have been described in physiologic conditions, inflammation, and cancer, prompting a series of questions on how adoptive immune responses, or tolerance, develop against tumors. Increasing evidence suggests that tumor treatments induce a dramatic change on tumor-infiltrating lymphocytes and, in particular, on some DC subtypes. In this review, we summarize the latest evidence on the role of DCs in cancer and preliminary evidence on chemotherapy-associated antigens identified in human cancers.
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spelling pubmed-38809352014-01-15 Therapeutic Implications of Immunogenic Cell Death in Human Cancer Palombo, Fabio Focaccetti, Chiara Barnaba, Vincenzo Front Immunol Immunology Dendritic cells (DCs) are central to the adoptive immune response, and their function is regulated by diverse signals in a context-specific manner. Different DCs have been described in physiologic conditions, inflammation, and cancer, prompting a series of questions on how adoptive immune responses, or tolerance, develop against tumors. Increasing evidence suggests that tumor treatments induce a dramatic change on tumor-infiltrating lymphocytes and, in particular, on some DC subtypes. In this review, we summarize the latest evidence on the role of DCs in cancer and preliminary evidence on chemotherapy-associated antigens identified in human cancers. Frontiers Media S.A. 2014-01-06 /pmc/articles/PMC3880935/ /pubmed/24432020 http://dx.doi.org/10.3389/fimmu.2013.00503 Text en Copyright © 2014 Palombo, Focaccetti and Barnaba. http://creativecommons.org/licenses/by/3.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Immunology
Palombo, Fabio
Focaccetti, Chiara
Barnaba, Vincenzo
Therapeutic Implications of Immunogenic Cell Death in Human Cancer
title Therapeutic Implications of Immunogenic Cell Death in Human Cancer
title_full Therapeutic Implications of Immunogenic Cell Death in Human Cancer
title_fullStr Therapeutic Implications of Immunogenic Cell Death in Human Cancer
title_full_unstemmed Therapeutic Implications of Immunogenic Cell Death in Human Cancer
title_short Therapeutic Implications of Immunogenic Cell Death in Human Cancer
title_sort therapeutic implications of immunogenic cell death in human cancer
topic Immunology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3880935/
https://www.ncbi.nlm.nih.gov/pubmed/24432020
http://dx.doi.org/10.3389/fimmu.2013.00503
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