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Over-expression of microRNA-494 up-regulates hypoxia-inducible factor-1 alpha expression via PI3K/Akt pathway and protects against hypoxia-induced apoptosis

BACKGROUND: Hypoxia-inducible factor-1 alpha (HIF-1α) is one of the key regulators of hypoxia/ischemia. MicroRNA-494 (miR-494) had cardioprotective effects against ischemia/reperfusion (I/R)-induced injury, but its functional relationship with HIF-1α was unknown. This study was undertaken to determi...

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Detalles Bibliográficos
Autores principales:	Sun, Guixiang, Zhou, Yanni, Li, Hongsheng, Guo, Yingjia, Shan, Juan, Xia, Mengjuan, Li, Youping, Li, Shengfu, Long, Dan, Feng, Li
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2013
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3881011/ https://www.ncbi.nlm.nih.gov/pubmed/24364919 http://dx.doi.org/10.1186/1423-0127-20-100

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