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Two-component systems in Streptomyces: key regulators of antibiotic complex pathways

Streptomyces, the main antibiotic-producing bacteria, responds to changing environmental conditions through a complex sensing mechanism and two-component systems (TCSs) play a crucial role in this extraordinary “sensing” device. Moreover, TCSs are involved in the biosynthetic control of a wide range...

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Detalles Bibliográficos
Autores principales: Rodríguez, Héctor, Rico, Sergio, Díaz, Margarita, Santamaría, Ramón I
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2013
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3881020/
https://www.ncbi.nlm.nih.gov/pubmed/24354561
http://dx.doi.org/10.1186/1475-2859-12-127
Descripción
Sumario:Streptomyces, the main antibiotic-producing bacteria, responds to changing environmental conditions through a complex sensing mechanism and two-component systems (TCSs) play a crucial role in this extraordinary “sensing” device. Moreover, TCSs are involved in the biosynthetic control of a wide range of secondary metabolites, among them commercial antibiotics. Increased knowledge about TCSs can be a powerful asset in the manipulation of bacteria through genetic engineering with a view to obtaining higher efficiencies in secondary metabolite production. In this review we summarise the available information about Streptomyces TCSs, focusing specifically on their connections to antibiotic production.