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Two-component systems in Streptomyces: key regulators of antibiotic complex pathways

Streptomyces, the main antibiotic-producing bacteria, responds to changing environmental conditions through a complex sensing mechanism and two-component systems (TCSs) play a crucial role in this extraordinary “sensing” device. Moreover, TCSs are involved in the biosynthetic control of a wide range...

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Autores principales: Rodríguez, Héctor, Rico, Sergio, Díaz, Margarita, Santamaría, Ramón I
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2013
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3881020/
https://www.ncbi.nlm.nih.gov/pubmed/24354561
http://dx.doi.org/10.1186/1475-2859-12-127
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author Rodríguez, Héctor
Rico, Sergio
Díaz, Margarita
Santamaría, Ramón I
author_facet Rodríguez, Héctor
Rico, Sergio
Díaz, Margarita
Santamaría, Ramón I
author_sort Rodríguez, Héctor
collection PubMed
description Streptomyces, the main antibiotic-producing bacteria, responds to changing environmental conditions through a complex sensing mechanism and two-component systems (TCSs) play a crucial role in this extraordinary “sensing” device. Moreover, TCSs are involved in the biosynthetic control of a wide range of secondary metabolites, among them commercial antibiotics. Increased knowledge about TCSs can be a powerful asset in the manipulation of bacteria through genetic engineering with a view to obtaining higher efficiencies in secondary metabolite production. In this review we summarise the available information about Streptomyces TCSs, focusing specifically on their connections to antibiotic production.
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spelling pubmed-38810202014-01-07 Two-component systems in Streptomyces: key regulators of antibiotic complex pathways Rodríguez, Héctor Rico, Sergio Díaz, Margarita Santamaría, Ramón I Microb Cell Fact Review Streptomyces, the main antibiotic-producing bacteria, responds to changing environmental conditions through a complex sensing mechanism and two-component systems (TCSs) play a crucial role in this extraordinary “sensing” device. Moreover, TCSs are involved in the biosynthetic control of a wide range of secondary metabolites, among them commercial antibiotics. Increased knowledge about TCSs can be a powerful asset in the manipulation of bacteria through genetic engineering with a view to obtaining higher efficiencies in secondary metabolite production. In this review we summarise the available information about Streptomyces TCSs, focusing specifically on their connections to antibiotic production. BioMed Central 2013-12-19 /pmc/articles/PMC3881020/ /pubmed/24354561 http://dx.doi.org/10.1186/1475-2859-12-127 Text en Copyright © 2013 Rodríguez et al.; licensee BioMed Central Ltd. http://creativecommons.org/licenses/by/2.0 This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.
spellingShingle Review
Rodríguez, Héctor
Rico, Sergio
Díaz, Margarita
Santamaría, Ramón I
Two-component systems in Streptomyces: key regulators of antibiotic complex pathways
title Two-component systems in Streptomyces: key regulators of antibiotic complex pathways
title_full Two-component systems in Streptomyces: key regulators of antibiotic complex pathways
title_fullStr Two-component systems in Streptomyces: key regulators of antibiotic complex pathways
title_full_unstemmed Two-component systems in Streptomyces: key regulators of antibiotic complex pathways
title_short Two-component systems in Streptomyces: key regulators of antibiotic complex pathways
title_sort two-component systems in streptomyces: key regulators of antibiotic complex pathways
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3881020/
https://www.ncbi.nlm.nih.gov/pubmed/24354561
http://dx.doi.org/10.1186/1475-2859-12-127
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